A model of recovery from inhalation injury and cutaneous burn in ambulatory swine

Highlights • Conscious, non-sedated swine recovered from combined burn and smoke inhalation injury. • Animals were followed for 2 weeks to identify the presence of late onset ARDS. • Lungs and airways appeared to recover starting on day 2 after-injury. • Cell content in BALF returned to baseline lev...

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Veröffentlicht in:	Burns 2017-09, Vol.43 (6), p.1295-1305
Hauptverfasser:	Burmeister, David M, McIntyre, Matthew K, Beely, Brendan, Jordan, Bryan, Walker, Kerfoot P, Aden, James K, Batchinsky, Andriy, Chung, Kevin K, Cancio, Leopoldo C, Christy, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchoscopy Burns Burns - diagnostic imaging Burns - immunology Burns - physiopathology Critical Care Cytokines Cytokines - immunology Disease Models, Animal Female Inhalation injury Interleukin 1 Receptor Antagonist Protein - metabolism Interleukin-12 - immunology Interleukin-8 - metabolism Intubation Leukocytes Lung - diagnostic imaging Lung - immunology Lung - pathology Lung - physiopathology Recovery of Function Respiration, Artificial Respiratory Distress Syndrome, Adult Smoke Inhalation Injury - diagnostic imaging Smoke Inhalation Injury - immunology Smoke Inhalation Injury - pathology Smoke Inhalation Injury - physiopathology Sus scrofa Swine Tomography, X-Ray Computed Tumor Necrosis Factor-alpha - immunology Wound Healing
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Beschreibung
Zusammenfassung:	Highlights • Conscious, non-sedated swine recovered from combined burn and smoke inhalation injury. • Animals were followed for 2 weeks to identify the presence of late onset ARDS. • Lungs and airways appeared to recover starting on day 2 after-injury. • Cell content in BALF returned to baseline levels by the end of the experiment, and correlated with levels in circulation. • Protein content in BALF also returned to baseline levels, but included a significant elevation in both IL1ra, and IL8.
ISSN:	0305-4179 1879-1409
DOI:	10.1016/j.burns.2017.03.010