Population pharmacokinetics of moxifloxacin, cycloserine, p -aminosalicylic acid and kanamycin for the treatment of multi-drug-resistant tuberculosis

Highlights • Population pharmacokinetic models of second-line anti-tuberculosis (TB) drugs in multi-drug-resistant TB were developed. • Dosages of second-line anti-TB drugs were slightly different from previous studies. • Pharmacokinetic parameters of moxifloxacin were influenced by patients' w...

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Veröffentlicht in:	International journal of antimicrobial agents 2017-06, Vol.49 (6), p.677-687
Hauptverfasser:	Chang, Min Jung, Jin, Byunghak, Chae, Jung-woo, Yun, Hwi-yeol, Kim, Eun Sun, Lee, Yeon Joo, Cho, Young-Jae, Yoon, Ho Il, Lee, Choon-Taek, Park, Kyoung Un, Song, Junghan, Lee, Jae-Ho, Park, Jong Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antitubercular Agents - administration & dosage Antitubercular Agents - pharmacokinetics Chromatography Female Humans Infectious Disease Injections, Intramuscular Male Middle Aged Models, Statistical Multi-drug-resistant tuberculosis Plasma - chemistry Population pharmacokinetics Prospective Studies Second-line anti-tuberculosis drugs Tandem Mass Spectrometry Tuberculosis, Multidrug-Resistant - drug therapy United States
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Zusammenfassung:	Highlights • Population pharmacokinetic models of second-line anti-tuberculosis (TB) drugs in multi-drug-resistant TB were developed. • Dosages of second-line anti-TB drugs were slightly different from previous studies. • Pharmacokinetic parameters of moxifloxacin were influenced by patients' weight.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2017.01.024