The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China
Investigate the expressions of WNTs in granulosa cells of PCOS in North China, and explore the possible mechanism. Patients with PCOS (n=40) and controls without PCOS (n=20) were enrolled into the study. The levels of serum sex hormone were detected by chemiluminescent enzyme immunoassay. RT-qPCR wa...
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| Veröffentlicht in: | Journal of gynecology obstetrics and human reproduction 2017-01, Vol.46 (1), p.93-99 |
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| creator | Wu, X.-q. Wang, Y.-q. Xu, S.-m. Liu, J.-f. Bi, X.-y. Wang, Z.-q. Zhang, J.-p. |
| description | Investigate the expressions of WNTs in granulosa cells of PCOS in North China, and explore the possible mechanism.
Patients with PCOS (n=40) and controls without PCOS (n=20) were enrolled into the study. The levels of serum sex hormone were detected by chemiluminescent enzyme immunoassay. RT-qPCR was used to measure mRNA levels of WNT family members (WNT1, WNT3, WNT4, WNT5, sFRP4 and sFRP5). The levels of Bax and Bcl-2 were measured by enzyme-linked immunosorbent assay.
The levels of PROG, TES and LH/FSH had difference (p |
| doi_str_mv | 10.1016/j.jgyn.2015.08.013 |
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Patients with PCOS (n=40) and controls without PCOS (n=20) were enrolled into the study. The levels of serum sex hormone were detected by chemiluminescent enzyme immunoassay. RT-qPCR was used to measure mRNA levels of WNT family members (WNT1, WNT3, WNT4, WNT5, sFRP4 and sFRP5). The levels of Bax and Bcl-2 were measured by enzyme-linked immunosorbent assay.
The levels of PROG, TES and LH/FSH had difference (p<0.05) on third day of menstrual cycle between PCOS and control groups. After injection of HCG, the levels of LH, E2 and PROG had significant difference (p<0.05). The PCOS group had higher transcript levels of WNT1, WNT3 and WNT4 (p<0.05), compared to controls. The level of secreted frizzled-related protein (sFRP4) was lower level in PCOS patients (p<0.05). In addition, we found a significant reduction of the β-catenin as well as the downstream targets (survivin and BMP4) (p<0.05). The level of Bax was significantly higher in PCOS group than in the control group (p<0.05). Above all, the WNT/β-catenin signaling pathway might be involved into granulosa cell apoptosis, which may provide a strategy for clinical treatment.
Étudier l’expression des WNT dans les cellules granulosa chez les patients souffrant du SOPK en Chine du Nord et explorer le mécanisme possible.
Des patients souffrant de SOPK (n=40) et des témoins sans SOPK (n=20) participaient à l’étude. Un dosage enzymo-immunologique par chimioluminescence était utilisé pour déterminer le taux plasmatique d’hormones sexuelles. RT-qPCR était utilisé pour mesurer les taux des ARN-messagers des membres de la famille WNT (WNT1, WNT3, WNT4, WNT5, sFRP4 et sFRP5). Les taux de Bax et de Bcl-2 étaient déterminés par Elisa.
Au troisième jour du cycle, les taux de PROG, de TES et de LH/FSH montraient des différences entre le groupe SOPK et le groupe témoin (p<0,05). Après injection d’HCG, les taux de LH, d’E2 et de PROG montraient une différence significative. Les taux des transcripts de WNT1, de WNT3 et de WNT4 étaient plus élevés dans le groupe SOPK (p<0,05) comparé au groupe témoin. Le taux de sFRP4 était plus bas dans le groupe SOPK (p<0,05). Nous avons trouvé, en plus, une réduction significative de la β-caténine et d’autres cibles en aval (survivine et BMP4) (p<0,05). Le taux de Bax était plus élevé dans le groupe SOPK que dans le groupe témoin (p<0,05). Surtout, la voie de signalisation WNT/β-caténine serait impliquée dans l’apoptose des cellules granulosa, suggérant une stratégie thérapeutique éventuelle.]]></description><identifier>ISSN: 2468-7847</identifier><identifier>EISSN: 2468-7847</identifier><identifier>DOI: 10.1016/j.jgyn.2015.08.013</identifier><identifier>PMID: 28403963</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Adult ; Apoptosis ; beta Catenin - genetics ; beta Catenin - metabolism ; Bone Morphogenetic Protein 4 - genetics ; Bone Morphogenetic Protein 4 - metabolism ; Case-Control Studies ; Cellules granulosa ; China ; Chorionic Gonadotropin - administration & dosage ; Eye Proteins - genetics ; Eye Proteins - metabolism ; Female ; Follicle Stimulating Hormone - blood ; Gonadal Steroid Hormones - blood ; Granulosa cells ; Granulosa Cells - pathology ; Humans ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - metabolism ; Luteinizing Hormone - blood ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - metabolism ; Polycystic Ovary Syndrome - pathology ; Prospective Studies ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - metabolism ; Real-Time Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Survivin - genetics ; Survivin - metabolism ; Syndrome des ovaires polykystiques ; Voie de signalisation WNT/β-caténine ; Wnt Signaling Pathway - genetics ; WNT/β-catenin signaling pathway</subject><ispartof>Journal of gynecology obstetrics and human reproduction, 2017-01, Vol.46 (1), p.93-99</ispartof><rights>2015 Elsevier Masson SAS</rights><rights>Copyright © 2015 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-79169f768cba7449ffbedfddb3631e1e2646f565804503e25dbc71515d11f48f3</citedby><cites>FETCH-LOGICAL-c356t-79169f768cba7449ffbedfddb3631e1e2646f565804503e25dbc71515d11f48f3</cites><orcidid>0000-0001-5044-9832</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27925,27926</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28403963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, X.-q.</creatorcontrib><creatorcontrib>Wang, Y.-q.</creatorcontrib><creatorcontrib>Xu, S.-m.</creatorcontrib><creatorcontrib>Liu, J.-f.</creatorcontrib><creatorcontrib>Bi, X.-y.</creatorcontrib><creatorcontrib>Wang, Z.-q.</creatorcontrib><creatorcontrib>Zhang, J.-p.</creatorcontrib><title>The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China</title><title>Journal of gynecology obstetrics and human reproduction</title><addtitle>J Gynecol Obstet Hum Reprod</addtitle><description><![CDATA[Investigate the expressions of WNTs in granulosa cells of PCOS in North China, and explore the possible mechanism.
Patients with PCOS (n=40) and controls without PCOS (n=20) were enrolled into the study. The levels of serum sex hormone were detected by chemiluminescent enzyme immunoassay. RT-qPCR was used to measure mRNA levels of WNT family members (WNT1, WNT3, WNT4, WNT5, sFRP4 and sFRP5). The levels of Bax and Bcl-2 were measured by enzyme-linked immunosorbent assay.
The levels of PROG, TES and LH/FSH had difference (p<0.05) on third day of menstrual cycle between PCOS and control groups. After injection of HCG, the levels of LH, E2 and PROG had significant difference (p<0.05). The PCOS group had higher transcript levels of WNT1, WNT3 and WNT4 (p<0.05), compared to controls. The level of secreted frizzled-related protein (sFRP4) was lower level in PCOS patients (p<0.05). In addition, we found a significant reduction of the β-catenin as well as the downstream targets (survivin and BMP4) (p<0.05). The level of Bax was significantly higher in PCOS group than in the control group (p<0.05). Above all, the WNT/β-catenin signaling pathway might be involved into granulosa cell apoptosis, which may provide a strategy for clinical treatment.
Étudier l’expression des WNT dans les cellules granulosa chez les patients souffrant du SOPK en Chine du Nord et explorer le mécanisme possible.
Des patients souffrant de SOPK (n=40) et des témoins sans SOPK (n=20) participaient à l’étude. Un dosage enzymo-immunologique par chimioluminescence était utilisé pour déterminer le taux plasmatique d’hormones sexuelles. RT-qPCR était utilisé pour mesurer les taux des ARN-messagers des membres de la famille WNT (WNT1, WNT3, WNT4, WNT5, sFRP4 et sFRP5). Les taux de Bax et de Bcl-2 étaient déterminés par Elisa.
Au troisième jour du cycle, les taux de PROG, de TES et de LH/FSH montraient des différences entre le groupe SOPK et le groupe témoin (p<0,05). Après injection d’HCG, les taux de LH, d’E2 et de PROG montraient une différence significative. Les taux des transcripts de WNT1, de WNT3 et de WNT4 étaient plus élevés dans le groupe SOPK (p<0,05) comparé au groupe témoin. Le taux de sFRP4 était plus bas dans le groupe SOPK (p<0,05). Nous avons trouvé, en plus, une réduction significative de la β-caténine et d’autres cibles en aval (survivine et BMP4) (p<0,05). Le taux de Bax était plus élevé dans le groupe SOPK que dans le groupe témoin (p<0,05). Surtout, la voie de signalisation WNT/β-caténine serait impliquée dans l’apoptose des cellules granulosa, suggérant une stratégie thérapeutique éventuelle.]]></description><subject>Adult</subject><subject>Apoptosis</subject><subject>beta Catenin - genetics</subject><subject>beta Catenin - metabolism</subject><subject>Bone Morphogenetic Protein 4 - genetics</subject><subject>Bone Morphogenetic Protein 4 - metabolism</subject><subject>Case-Control Studies</subject><subject>Cellules granulosa</subject><subject>China</subject><subject>Chorionic Gonadotropin - administration & dosage</subject><subject>Eye Proteins - genetics</subject><subject>Eye Proteins - metabolism</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>Granulosa cells</subject><subject>Granulosa Cells - pathology</subject><subject>Humans</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Luteinizing Hormone - blood</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>Polycystic Ovary Syndrome - pathology</subject><subject>Prospective Studies</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Survivin - genetics</subject><subject>Survivin - metabolism</subject><subject>Syndrome des ovaires polykystiques</subject><subject>Voie de signalisation WNT/β-caténine</subject><subject>Wnt Signaling Pathway - genetics</subject><subject>WNT/β-catenin signaling pathway</subject><issn>2468-7847</issn><issn>2468-7847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVpaEKSF-ih6NiLHcm2ZC30UpamCYSk0C09Clka7WqxJVfy7rKv1QfJM0Vm09JTD8PMwP__zHwIvaekpITym225XR99WRHKSiJKQus36KJquCha0bRv_5nP0XVKW0IIFRXnNX-HzivRkHrB6wt0WG0A_3xc3Tz_LrSawDuPk1t71Tu_xqOaNgd1xEOuDrDz-9DvweQBr6Pyuz4khTX0PVZjGKeQXMI2hmE2OvBTwgc3bfC35dP32fMYYt6WG-fVFTqzqk9w_dov0Y_bL6vlXfHw9PV--fmh0DXjU9EuKF_YlgvdqbZpFtZ2YKwxXc1rChQq3nDLOBOkYaSGiplOt5RRZii1jbD1Jfp4yh1j-LWDNMnBpfli5SHskqRCtE3FGKVZWp2kOoaUIlg5RjeoeJSUyJm53MqZuZyZSyJkZp5NH17zd90A5q_lD-Es-HQSQP5y7yDKpDMaDcZF0JM0wf0v_wWeR5PK</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Wu, X.-q.</creator><creator>Wang, Y.-q.</creator><creator>Xu, S.-m.</creator><creator>Liu, J.-f.</creator><creator>Bi, X.-y.</creator><creator>Wang, Z.-q.</creator><creator>Zhang, J.-p.</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5044-9832</orcidid></search><sort><creationdate>201701</creationdate><title>The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China</title><author>Wu, X.-q. ; Wang, Y.-q. ; Xu, S.-m. ; Liu, J.-f. ; Bi, X.-y. ; Wang, Z.-q. ; Zhang, J.-p.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-79169f768cba7449ffbedfddb3631e1e2646f565804503e25dbc71515d11f48f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Apoptosis</topic><topic>beta Catenin - genetics</topic><topic>beta Catenin - metabolism</topic><topic>Bone Morphogenetic Protein 4 - genetics</topic><topic>Bone Morphogenetic Protein 4 - metabolism</topic><topic>Case-Control Studies</topic><topic>Cellules granulosa</topic><topic>China</topic><topic>Chorionic Gonadotropin - administration & dosage</topic><topic>Eye Proteins - genetics</topic><topic>Eye Proteins - metabolism</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>Granulosa cells</topic><topic>Granulosa Cells - pathology</topic><topic>Humans</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Luteinizing Hormone - blood</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>Polycystic Ovary Syndrome - pathology</topic><topic>Prospective Studies</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Survivin - genetics</topic><topic>Survivin - metabolism</topic><topic>Syndrome des ovaires polykystiques</topic><topic>Voie de signalisation WNT/β-caténine</topic><topic>Wnt Signaling Pathway - genetics</topic><topic>WNT/β-catenin signaling pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, X.-q.</creatorcontrib><creatorcontrib>Wang, Y.-q.</creatorcontrib><creatorcontrib>Xu, S.-m.</creatorcontrib><creatorcontrib>Liu, J.-f.</creatorcontrib><creatorcontrib>Bi, X.-y.</creatorcontrib><creatorcontrib>Wang, Z.-q.</creatorcontrib><creatorcontrib>Zhang, J.-p.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gynecology obstetrics and human reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, X.-q.</au><au>Wang, Y.-q.</au><au>Xu, S.-m.</au><au>Liu, J.-f.</au><au>Bi, X.-y.</au><au>Wang, Z.-q.</au><au>Zhang, J.-p.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China</atitle><jtitle>Journal of gynecology obstetrics and human reproduction</jtitle><addtitle>J Gynecol Obstet Hum Reprod</addtitle><date>2017-01</date><risdate>2017</risdate><volume>46</volume><issue>1</issue><spage>93</spage><epage>99</epage><pages>93-99</pages><issn>2468-7847</issn><eissn>2468-7847</eissn><abstract><![CDATA[Investigate the expressions of WNTs in granulosa cells of PCOS in North China, and explore the possible mechanism.
Patients with PCOS (n=40) and controls without PCOS (n=20) were enrolled into the study. The levels of serum sex hormone were detected by chemiluminescent enzyme immunoassay. RT-qPCR was used to measure mRNA levels of WNT family members (WNT1, WNT3, WNT4, WNT5, sFRP4 and sFRP5). The levels of Bax and Bcl-2 were measured by enzyme-linked immunosorbent assay.
The levels of PROG, TES and LH/FSH had difference (p<0.05) on third day of menstrual cycle between PCOS and control groups. After injection of HCG, the levels of LH, E2 and PROG had significant difference (p<0.05). The PCOS group had higher transcript levels of WNT1, WNT3 and WNT4 (p<0.05), compared to controls. The level of secreted frizzled-related protein (sFRP4) was lower level in PCOS patients (p<0.05). In addition, we found a significant reduction of the β-catenin as well as the downstream targets (survivin and BMP4) (p<0.05). The level of Bax was significantly higher in PCOS group than in the control group (p<0.05). Above all, the WNT/β-catenin signaling pathway might be involved into granulosa cell apoptosis, which may provide a strategy for clinical treatment.
Étudier l’expression des WNT dans les cellules granulosa chez les patients souffrant du SOPK en Chine du Nord et explorer le mécanisme possible.
Des patients souffrant de SOPK (n=40) et des témoins sans SOPK (n=20) participaient à l’étude. Un dosage enzymo-immunologique par chimioluminescence était utilisé pour déterminer le taux plasmatique d’hormones sexuelles. RT-qPCR était utilisé pour mesurer les taux des ARN-messagers des membres de la famille WNT (WNT1, WNT3, WNT4, WNT5, sFRP4 et sFRP5). Les taux de Bax et de Bcl-2 étaient déterminés par Elisa.
Au troisième jour du cycle, les taux de PROG, de TES et de LH/FSH montraient des différences entre le groupe SOPK et le groupe témoin (p<0,05). Après injection d’HCG, les taux de LH, d’E2 et de PROG montraient une différence significative. Les taux des transcripts de WNT1, de WNT3 et de WNT4 étaient plus élevés dans le groupe SOPK (p<0,05) comparé au groupe témoin. Le taux de sFRP4 était plus bas dans le groupe SOPK (p<0,05). Nous avons trouvé, en plus, une réduction significative de la β-caténine et d’autres cibles en aval (survivine et BMP4) (p<0,05). Le taux de Bax était plus élevé dans le groupe SOPK que dans le groupe témoin (p<0,05). Surtout, la voie de signalisation WNT/β-caténine serait impliquée dans l’apoptose des cellules granulosa, suggérant une stratégie thérapeutique éventuelle.]]></abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>28403963</pmid><doi>10.1016/j.jgyn.2015.08.013</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5044-9832</orcidid></addata></record> |
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| ispartof | Journal of gynecology obstetrics and human reproduction, 2017-01, Vol.46 (1), p.93-99 |
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| subjects | Adult Apoptosis beta Catenin - genetics beta Catenin - metabolism Bone Morphogenetic Protein 4 - genetics Bone Morphogenetic Protein 4 - metabolism Case-Control Studies Cellules granulosa China Chorionic Gonadotropin - administration & dosage Eye Proteins - genetics Eye Proteins - metabolism Female Follicle Stimulating Hormone - blood Gonadal Steroid Hormones - blood Granulosa cells Granulosa Cells - pathology Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Luteinizing Hormone - blood Membrane Proteins - genetics Membrane Proteins - metabolism Polycystic ovary syndrome Polycystic Ovary Syndrome - metabolism Polycystic Ovary Syndrome - pathology Prospective Studies Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Real-Time Polymerase Chain Reaction RNA, Messenger - metabolism Survivin - genetics Survivin - metabolism Syndrome des ovaires polykystiques Voie de signalisation WNT/β-caténine Wnt Signaling Pathway - genetics WNT/β-catenin signaling pathway |
| title | The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China |
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