The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China

Investigate the expressions of WNTs in granulosa cells of PCOS in North China, and explore the possible mechanism. Patients with PCOS (n=40) and controls without PCOS (n=20) were enrolled into the study. The levels of serum sex hormone were detected by chemiluminescent enzyme immunoassay. RT-qPCR wa...

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Veröffentlicht in:	Journal of gynecology obstetrics and human reproduction 2017-01, Vol.46 (1), p.93-99
Hauptverfasser:	Wu, X.-q., Wang, Y.-q., Xu, S.-m., Liu, J.-f., Bi, X.-y., Wang, Z.-q., Zhang, J.-p.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis beta Catenin - genetics beta Catenin - metabolism Bone Morphogenetic Protein 4 - genetics Bone Morphogenetic Protein 4 - metabolism Case-Control Studies Cellules granulosa China Chorionic Gonadotropin - administration & dosage Eye Proteins - genetics Eye Proteins - metabolism Female Follicle Stimulating Hormone - blood Gonadal Steroid Hormones - blood Granulosa cells Granulosa Cells - pathology Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Luteinizing Hormone - blood Membrane Proteins - genetics Membrane Proteins - metabolism Polycystic ovary syndrome Polycystic Ovary Syndrome - metabolism Polycystic Ovary Syndrome - pathology Prospective Studies Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Real-Time Polymerase Chain Reaction RNA, Messenger - metabolism Survivin - genetics Survivin - metabolism Syndrome des ovaires polykystiques Voie de signalisation WNT/β-caténine Wnt Signaling Pathway - genetics WNT/β-catenin signaling pathway
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Zusammenfassung:	Investigate the expressions of WNTs in granulosa cells of PCOS in North China, and explore the possible mechanism. Patients with PCOS (n=40) and controls without PCOS (n=20) were enrolled into the study. The levels of serum sex hormone were detected by chemiluminescent enzyme immunoassay. RT-qPCR was used to measure mRNA levels of WNT family members (WNT1, WNT3, WNT4, WNT5, sFRP4 and sFRP5). The levels of Bax and Bcl-2 were measured by enzyme-linked immunosorbent assay. The levels of PROG, TES and LH/FSH had difference (p
ISSN:	2468-7847 2468-7847
DOI:	10.1016/j.jgyn.2015.08.013