Callyspongenols A-C, New Cytotoxic C sub(22)-Polyacetylenic Alcohols from a Red Sea Sponge, Callyspongia Species

Callyspongenols A-C, New Cytotoxic C sub(22)-Polyacetylenic Alcohols from a Red Sea Sponge, Callyspongia Species

Investigation of the organic extract of a Red Sea sponge, Callyspongia sp., resulted in isolation and identification of three new C sub(22)-polyacetylenic alcohols, callyspongenols A-C (1-3), together with dehydroisophonochalynol (4). The structures of 1-3 were determined by 1D and 2D NMR studies an...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2003-05, Vol.66 (5), p.679-681
Hauptverfasser: Youssef, DTA, van Soest, RWM, Fusetani, Nobuhiro
Format: Artikel
Sprache:eng
Schlagworte:
alcohols
Callyspongenols
Callyspongia
natural products
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Zusammenfassung:Investigation of the organic extract of a Red Sea sponge, Callyspongia sp., resulted in isolation and identification of three new C sub(22)-polyacetylenic alcohols, callyspongenols A-C (1-3), together with dehydroisophonochalynol (4). The structures of 1-3 were determined by 1D and 2D NMR studies and mass spectral determinations. Compounds 1-4 showed moderate cytotoxicity against P388 and HeLa cells.
ISSN:0163-3864
DOI:10.1021/np030006c