Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow

Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow

Differentiation of hematopoietic stem cells into distinct cell types was thought to occur through a series of discrete, stable progenitor states. Work from Velten et al. (2017) now shows that hematopoietic cells differentiate via a mechanism of continuous lineage priming and thus represent a CLOUD-H...

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Veröffentlicht in:Developmental cell 2017-04, Vol.41 (1), p.7-9
Hauptverfasser: Hirschi, Karen K., Nicoli, Stefania, Walsh, Kenneth
Format: Artikel
Sprache:eng
Schlagworte:
Cell Differentiation
Cell Lineage
Hematopoiesis
Hematopoietic Stem Cells - cytology
Trees
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Zusammenfassung:Differentiation of hematopoietic stem cells into distinct cell types was thought to occur through a series of discrete, stable progenitor states. Work from Velten et al. (2017) now shows that hematopoietic cells differentiate via a mechanism of continuous lineage priming and thus represent a CLOUD-HSPC. Differentiation of hematopoietic stem cells into distinct cell types was thought to occur through a series of discrete, stable progenitor states. Work from Velten et al. (2017) now shows that hematopoietic cells differentiate via a mechanism of continuous lineage priming and thus represent a CLOUD-HSPC.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2017.03.020