Recurring Thrombocytopenia Associated with Structured Treatment Interruption in Patients with Human Immunodeficiency Virus Infection

In a structured treatment interruption (STI) trial, 3 of 23 patients in a CD4 cell count-guided treatment arm developed recurring thrombocytopenia associated with the interruption of antiretroviral therapy. All 3 patients had slightly low or normal platelet counts before initiating antiretroviral th...

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Veröffentlicht in:	Clinical infectious diseases 2003-09, Vol.37 (5), p.723-725
Hauptverfasser:	Ananworanich, Jintanat, Phanuphak, Nittaya, Nuesch, Reto, Apateerapong, Wichitra, Rojnuckarin, Ponlapat, Ubolyam, Sasiwimol, Phanuphak, Praphan, Ruxrungtham, Kiat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS Antibodies Antiretrovirals Biological and medical sciences CD4 Lymphocyte Count Drug Administration Schedule Hematologic and hematopoietic diseases Highly active antiretroviral therapy HIV HIV infections HIV Infections - drug therapy HIV Infections - enzymology HIV Protease Inhibitors - adverse effects HIV Protease Inhibitors - therapeutic use HIV/AIDS Human viral diseases Humans Infections Infectious diseases Male Medical sciences Middle Aged Platelet Count Platelet diseases and coagulopathies Platelets Randomized Controlled Trials as Topic Recurrence Reverse Transcriptase Inhibitors - adverse effects Reverse Transcriptase Inhibitors - therapeutic use Thrombocytopenia Thrombocytopenia - etiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viruses
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Beschreibung
Zusammenfassung:	In a structured treatment interruption (STI) trial, 3 of 23 patients in a CD4 cell count-guided treatment arm developed recurring thrombocytopenia associated with the interruption of antiretroviral therapy. All 3 patients had slightly low or normal platelet counts before initiating antiretroviral therapy. STI may play a role in inducing thrombocytopenia in patients with human immunodeficiency virus infection.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/376989