RGD-mediated delivery of small-molecule drugs

Conjugates of cytotoxic agents with RGD peptides (Arg-Gly-Asp) addressed to α β , α β and α β integrin receptors overexpressed by cancer cells, have recently gained attention as potential selective anticancer chemotherapeutics. In this review, the design and the development of RGD conjugates coupled...

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Veröffentlicht in:	Future medicinal chemistry 2017-04, Vol.9 (6), p.579-604
Hauptverfasser:	Katsamakas, Sotirios, Chatzisideri, Theodora, Thysiadis, Savvas, Sarli, Vasiliki
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Biological Products - administration & dosage Biological Products - chemistry Cell Proliferation - drug effects Drug Delivery Systems Humans integrin a Integrins - metabolism Molecular Structure Oligopeptides - metabolism RGD conjugates RGD peptide Small Molecule Libraries - administration & dosage Small Molecule Libraries - chemistry targeted drug delivery tumor therapy
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