RGD-mediated delivery of small-molecule drugs

Conjugates of cytotoxic agents with RGD peptides (Arg-Gly-Asp) addressed to α β , α β and α β integrin receptors overexpressed by cancer cells, have recently gained attention as potential selective anticancer chemotherapeutics. In this review, the design and the development of RGD conjugates coupled...

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Veröffentlicht in:	Future medicinal chemistry 2017-04, Vol.9 (6), p.579-604
Hauptverfasser:	Katsamakas, Sotirios, Chatzisideri, Theodora, Thysiadis, Savvas, Sarli, Vasiliki
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Biological Products - administration & dosage Biological Products - chemistry Cell Proliferation - drug effects Drug Delivery Systems Humans integrin a Integrins - metabolism Molecular Structure Oligopeptides - metabolism RGD conjugates RGD peptide Small Molecule Libraries - administration & dosage Small Molecule Libraries - chemistry targeted drug delivery tumor therapy
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Beschreibung
Zusammenfassung:	Conjugates of cytotoxic agents with RGD peptides (Arg-Gly-Asp) addressed to α β , α β and α β integrin receptors overexpressed by cancer cells, have recently gained attention as potential selective anticancer chemotherapeutics. In this review, the design and the development of RGD conjugates coupled to different small molecules including known cytotoxic drugs and natural products will be discussed.
ISSN:	1756-8919 1756-8927
DOI:	10.4155/fmc-2017-0008