Molecular Mechanisms of Brain-Derived Neurotrophic Factor in Neuro- protection: Recent Developments
Highlights • Neuronal cell injury is the primary pathological mechanism responsible for most types of brain injury. • Brain-derived neurotrophic factor (BDNF) may facilitate protective and regenerative effects following injury. • BDNF is involved in several pathological conditions, including hypoxic...
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| Veröffentlicht in: | Brain research 2017-06, Vol.1665, p.1-21 |
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| container_title | Brain research |
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| creator | Zhao, Hailin Alam, Azeem San, Chun-Yin Eguchi, Shiori Chen, Qian Lian, Qingquan Ma, Daqing |
| description | Highlights • Neuronal cell injury is the primary pathological mechanism responsible for most types of brain injury. • Brain-derived neurotrophic factor (BDNF) may facilitate protective and regenerative effects following injury. • BDNF is involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer’s disease and Parkinson’s disease. • Targeting BDNF can be applied in clinical settings and can serve as a new therapeutic strategy against neuronal injury. |
| doi_str_mv | 10.1016/j.brainres.2017.03.029 |
| format | Article |
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Alam, Azeem ; San, Chun-Yin ; Eguchi, Shiori ; Chen, Qian ; Lian, Qingquan ; Ma, Daqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-5b9f585c4ac778a8593a43b3a492c6fe8cb62b8d9976a7bd6948fd59fbc656f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - therapy</topic><topic>Animals</topic><topic>Brain - metabolism</topic><topic>Brain injury</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Humans</topic><topic>Hypoxia, Brain - metabolism</topic><topic>Hypoxia, Brain - therapy</topic><topic>Neurology</topic><topic>Neurons - metabolism</topic><topic>Neuroprotection</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson Disease - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Hailin</creatorcontrib><creatorcontrib>Alam, Azeem</creatorcontrib><creatorcontrib>San, Chun-Yin</creatorcontrib><creatorcontrib>Eguchi, Shiori</creatorcontrib><creatorcontrib>Chen, Qian</creatorcontrib><creatorcontrib>Lian, Qingquan</creatorcontrib><creatorcontrib>Ma, Daqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Hailin</au><au>Alam, Azeem</au><au>San, Chun-Yin</au><au>Eguchi, Shiori</au><au>Chen, Qian</au><au>Lian, Qingquan</au><au>Ma, Daqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Mechanisms of Brain-Derived Neurotrophic Factor in Neuro- protection: Recent Developments</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2017-06-15</date><risdate>2017</risdate><volume>1665</volume><spage>1</spage><epage>21</epage><pages>1-21</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Highlights • Neuronal cell injury is the primary pathological mechanism responsible for most types of brain injury. • Brain-derived neurotrophic factor (BDNF) may facilitate protective and regenerative effects following injury. • BDNF is involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer’s disease and Parkinson’s disease. • Targeting BDNF can be applied in clinical settings and can serve as a new therapeutic strategy against neuronal injury.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28396009</pmid><doi>10.1016/j.brainres.2017.03.029</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-0688-2097</orcidid></addata></record> |
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| ispartof | Brain research, 2017-06, Vol.1665, p.1-21 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alzheimer Disease - metabolism Alzheimer Disease - therapy Animals Brain - metabolism Brain injury Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Humans Hypoxia, Brain - metabolism Hypoxia, Brain - therapy Neurology Neurons - metabolism Neuroprotection Parkinson Disease - metabolism Parkinson Disease - therapy |
| title | Molecular Mechanisms of Brain-Derived Neurotrophic Factor in Neuro- protection: Recent Developments |
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