Molecular Mechanisms of Brain-Derived Neurotrophic Factor in Neuro- protection: Recent Developments

Highlights • Neuronal cell injury is the primary pathological mechanism responsible for most types of brain injury. • Brain-derived neurotrophic factor (BDNF) may facilitate protective and regenerative effects following injury. • BDNF is involved in several pathological conditions, including hypoxic...

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Veröffentlicht in:	Brain research 2017-06, Vol.1665, p.1-21
Hauptverfasser:	Zhao, Hailin, Alam, Azeem, San, Chun-Yin, Eguchi, Shiori, Chen, Qian, Lian, Qingquan, Ma, Daqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - therapy Animals Brain - metabolism Brain injury Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Humans Hypoxia, Brain - metabolism Hypoxia, Brain - therapy Neurology Neurons - metabolism Neuroprotection Parkinson Disease - metabolism Parkinson Disease - therapy
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Beschreibung
Zusammenfassung:	Highlights • Neuronal cell injury is the primary pathological mechanism responsible for most types of brain injury. • Brain-derived neurotrophic factor (BDNF) may facilitate protective and regenerative effects following injury. • BDNF is involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer’s disease and Parkinson’s disease. • Targeting BDNF can be applied in clinical settings and can serve as a new therapeutic strategy against neuronal injury.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2017.03.029