Cancer-testis antigen expression is shared between epithelial ovarian cancer tumors
Highlights • Heterogeneous expression of Cancer-testis antigens was found in epithelial ovarian cancer (EOC) tumors. • Cancer-testis antigen expression is shared between EOC tumors. • MAGE-A4, MAGE-A1, MAGE-A3, OY-TES-1 and MAGE-C1 being shared among 95% of all specimens analyzed. • SP17, GAGE, NY-E...
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| Veröffentlicht in: | Gynecologic oncology 2017-06, Vol.145 (3), p.413-419 |
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| container_title | Gynecologic oncology |
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| creator | Garcia-Soto, Arlene E Schreiber, Taylor Strbo, Natasa Ganjei-Azar, Parvin Miao, Feng Koru-Sengul, Tulay Simpkins, Fiona Nieves-Neira, Wilberto Lucci, Joseph Podack, Eckhard R |
| description | Highlights • Heterogeneous expression of Cancer-testis antigens was found in epithelial ovarian cancer (EOC) tumors. • Cancer-testis antigen expression is shared between EOC tumors. • MAGE-A4, MAGE-A1, MAGE-A3, OY-TES-1 and MAGE-C1 being shared among 95% of all specimens analyzed. • SP17, GAGE, NY-ESO-1 and XAGE-1D expression associated with higher risk of disease progression. • A multi-antigen vaccination strategy could be a more suitable immunotherapeutic approach in EOC. |
| doi_str_mv | 10.1016/j.ygyno.2017.03.512 |
| format | Article |
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Schreiber, Taylor ; Strbo, Natasa ; Ganjei-Azar, Parvin ; Miao, Feng ; Koru-Sengul, Tulay ; Simpkins, Fiona ; Nieves-Neira, Wilberto ; Lucci, Joseph ; Podack, Eckhard R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-ce39d8adf9497fec56cbc5b65511ffb68913e56f30a88c09d2b8c0cc12ed905a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigen sharing</topic><topic>Antigens, Neoplasm - biosynthesis</topic><topic>Antigens, Neoplasm - genetics</topic><topic>Antigens, Neoplasm - immunology</topic><topic>Cancer Vaccines - immunology</topic><topic>Cancer-testis antigens</topic><topic>Carcinoma, Ovarian Epithelial</topic><topic>Cell Line, Tumor</topic><topic>Epithelial ovarian cancer</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasms, Glandular and Epithelial - genetics</topic><topic>Neoplasms, Glandular and Epithelial - immunology</topic><topic>Neoplasms, Glandular and Epithelial - pathology</topic><topic>Obstetrics and Gynecology</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - immunology</topic><topic>Ovarian Neoplasms - pathology</topic><topic>RNA, Neoplasm - genetics</topic><topic>RNA, Neoplasm - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Soto, Arlene E</creatorcontrib><creatorcontrib>Schreiber, Taylor</creatorcontrib><creatorcontrib>Strbo, Natasa</creatorcontrib><creatorcontrib>Ganjei-Azar, Parvin</creatorcontrib><creatorcontrib>Miao, Feng</creatorcontrib><creatorcontrib>Koru-Sengul, Tulay</creatorcontrib><creatorcontrib>Simpkins, Fiona</creatorcontrib><creatorcontrib>Nieves-Neira, Wilberto</creatorcontrib><creatorcontrib>Lucci, Joseph</creatorcontrib><creatorcontrib>Podack, Eckhard R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Soto, Arlene E</au><au>Schreiber, Taylor</au><au>Strbo, Natasa</au><au>Ganjei-Azar, Parvin</au><au>Miao, Feng</au><au>Koru-Sengul, Tulay</au><au>Simpkins, Fiona</au><au>Nieves-Neira, Wilberto</au><au>Lucci, Joseph</au><au>Podack, Eckhard R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer-testis antigen expression is shared between epithelial ovarian cancer tumors</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>145</volume><issue>3</issue><spage>413</spage><epage>419</epage><pages>413-419</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><abstract>Highlights • Heterogeneous expression of Cancer-testis antigens was found in epithelial ovarian cancer (EOC) tumors. • Cancer-testis antigen expression is shared between EOC tumors. • MAGE-A4, MAGE-A1, MAGE-A3, OY-TES-1 and MAGE-C1 being shared among 95% of all specimens analyzed. • SP17, GAGE, NY-ESO-1 and XAGE-1D expression associated with higher risk of disease progression. • A multi-antigen vaccination strategy could be a more suitable immunotherapeutic approach in EOC.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28392126</pmid><doi>10.1016/j.ygyno.2017.03.512</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1566-7345</orcidid></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antigen sharing Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Cancer Vaccines - immunology Cancer-testis antigens Carcinoma, Ovarian Epithelial Cell Line, Tumor Epithelial ovarian cancer Female Hematology, Oncology and Palliative Medicine Humans Middle Aged Neoplasm Grading Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - immunology Neoplasms, Glandular and Epithelial - pathology Obstetrics and Gynecology Ovarian Neoplasms - genetics Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology RNA, Neoplasm - genetics RNA, Neoplasm - immunology Young Adult |
| title | Cancer-testis antigen expression is shared between epithelial ovarian cancer tumors |
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