Cancer-testis antigen expression is shared between epithelial ovarian cancer tumors

Highlights • Heterogeneous expression of Cancer-testis antigens was found in epithelial ovarian cancer (EOC) tumors. • Cancer-testis antigen expression is shared between EOC tumors. • MAGE-A4, MAGE-A1, MAGE-A3, OY-TES-1 and MAGE-C1 being shared among 95% of all specimens analyzed. • SP17, GAGE, NY-E...

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Veröffentlicht in:	Gynecologic oncology 2017-06, Vol.145 (3), p.413-419
Hauptverfasser:	Garcia-Soto, Arlene E, Schreiber, Taylor, Strbo, Natasa, Ganjei-Azar, Parvin, Miao, Feng, Koru-Sengul, Tulay, Simpkins, Fiona, Nieves-Neira, Wilberto, Lucci, Joseph, Podack, Eckhard R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antigen sharing Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Cancer Vaccines - immunology Cancer-testis antigens Carcinoma, Ovarian Epithelial Cell Line, Tumor Epithelial ovarian cancer Female Hematology, Oncology and Palliative Medicine Humans Middle Aged Neoplasm Grading Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - immunology Neoplasms, Glandular and Epithelial - pathology Obstetrics and Gynecology Ovarian Neoplasms - genetics Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology RNA, Neoplasm - genetics RNA, Neoplasm - immunology Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Heterogeneous expression of Cancer-testis antigens was found in epithelial ovarian cancer (EOC) tumors. • Cancer-testis antigen expression is shared between EOC tumors. • MAGE-A4, MAGE-A1, MAGE-A3, OY-TES-1 and MAGE-C1 being shared among 95% of all specimens analyzed. • SP17, GAGE, NY-ESO-1 and XAGE-1D expression associated with higher risk of disease progression. • A multi-antigen vaccination strategy could be a more suitable immunotherapeutic approach in EOC.
ISSN:	0090-8258 1095-6859
DOI:	10.1016/j.ygyno.2017.03.512