Metabolic systems modeling for cell factories improvement

Metabolic systems modeling for cell factories improvement

Highlights • Recent developments of mathematical modeling have facilitated strain design. • Robustness for stability has emerged as an important criterion for strain design. • Data acquisition and managing techniques are in need in modern systems biology.

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Bibliographische Detailangaben
Veröffentlicht in:Current opinion in biotechnology 2017-08, Vol.46, p.114-119
Hauptverfasser: Chen, Po-Wei, Theisen, Matthew K, Liao, James C
Format: Artikel
Sprache:eng
Schlagworte:
Cells - metabolism
Internal Medicine
Kinetics
Metabolic Engineering - methods
Metabolic Flux Analysis
Models, Biological
Systems Biology - methods
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Beschreibung
Zusammenfassung:Highlights • Recent developments of mathematical modeling have facilitated strain design. • Robustness for stability has emerged as an important criterion for strain design. • Data acquisition and managing techniques are in need in modern systems biology.
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2017.02.005