Sustainable Difluoroalkylation Cyclization Cascades of 1,8-Enynes
We reported a visible-light-induced difluoroalkylation and cyclization cascade reaction of 1,8-enynes with broad substrate scopes in up to 92% isolated yields. This method provides a sustainable and efficient access to the synthesis of difluoroalkylated tetracyclic compounds under mild conditions.
Gespeichert in:
| Veröffentlicht in: | Journal of organic chemistry 2017-04, Vol.82 (8), p.4449-4457 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | We reported a visible-light-induced difluoroalkylation and cyclization cascade reaction of 1,8-enynes with broad substrate scopes in up to 92% isolated yields. This method provides a sustainable and efficient access to the synthesis of difluoroalkylated tetracyclic compounds under mild conditions. |
|---|---|
| ISSN: | 0022-3263 1520-6904 |
| DOI: | 10.1021/acs.joc.7b00350 |