Minor Steroidal Alkaloids from the Marine Sponge Corticium sp.
Four new steroidal alkaloids, plakinamine G (1), plakinamine H (2), 4α-hydroxydemethylplakinamine B (3), and tetrahydroplakinamine A (4), along with three known compounds, were isolated from the marine sponge Corticium sp. The structures of these metabolites were elucidated largely by 1D and 2D NMR...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2002-08, Vol.65 (8), p.1206-1209 |
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| container_issue | 8 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 65 |
| creator | Borbone, Nicola De Marino, Simona Iorizzi, Maria Zollo, Franco Debitus, Cecile Esposito, Giuseppe Iuvone, Teresa |
| description | Four new steroidal alkaloids, plakinamine G (1), plakinamine H (2), 4α-hydroxydemethylplakinamine B (3), and tetrahydroplakinamine A (4), along with three known compounds, were isolated from the marine sponge Corticium sp. The structures of these metabolites were elucidated largely by 1D and 2D NMR methods and accurate mass measurements (HR-EIMS). Compounds 1, 2, and 4 show significant in vitro cytotoxicity. |
| doi_str_mv | 10.1021/np020027r |
| format | Article |
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The structures of these metabolites were elucidated largely by 1D and 2D NMR methods and accurate mass measurements (HR-EIMS). Compounds 1, 2, and 4 show significant in vitro cytotoxicity.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np020027r</identifier><identifier>PMID: 12193035</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>4 alpha -hydroxydemethylplakinamine B ; Alkaloids - chemistry ; Alkaloids - isolation & purification ; Alkaloids - pharmacology ; Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Cells, Cultured - drug effects ; Chromatography, High Pressure Liquid ; Corticium ; Dose-Response Relationship, Drug ; General pharmacology ; Glioma ; Inhibitory Concentration 50 ; Macrophages - drug effects ; Marine ; Medical sciences ; Mice ; Molecular Conformation ; Molecular Structure ; natural products ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plakinamine G ; plakinamine H ; Porifera - chemistry ; Rats ; steroidal alkaloids ; Steroids - chemistry ; Steroids - isolation & purification ; Steroids - pharmacology ; tetrahydroplakinamine A ; Vanuatu</subject><ispartof>Journal of natural products (Washington, D.C.), 2002-08, Vol.65 (8), p.1206-1209</ispartof><rights>Copyright © 2002 American Chemical Society and American Society of Pharmacognosy</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a410t-6f523a28211850f3763ede1a8844de540e776ab2292028197c07408728cb04363</citedby><cites>FETCH-LOGICAL-a410t-6f523a28211850f3763ede1a8844de540e776ab2292028197c07408728cb04363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np020027r$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np020027r$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13880894$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12193035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borbone, Nicola</creatorcontrib><creatorcontrib>De Marino, Simona</creatorcontrib><creatorcontrib>Iorizzi, Maria</creatorcontrib><creatorcontrib>Zollo, Franco</creatorcontrib><creatorcontrib>Debitus, Cecile</creatorcontrib><creatorcontrib>Esposito, Giuseppe</creatorcontrib><creatorcontrib>Iuvone, Teresa</creatorcontrib><title>Minor Steroidal Alkaloids from the Marine Sponge Corticium sp.</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Four new steroidal alkaloids, plakinamine G (1), plakinamine H (2), 4α-hydroxydemethylplakinamine B (3), and tetrahydroplakinamine A (4), along with three known compounds, were isolated from the marine sponge Corticium sp. The structures of these metabolites were elucidated largely by 1D and 2D NMR methods and accurate mass measurements (HR-EIMS). Compounds 1, 2, and 4 show significant in vitro cytotoxicity.</description><subject>4 alpha -hydroxydemethylplakinamine B</subject><subject>Alkaloids - chemistry</subject><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Corticium</subject><subject>Dose-Response Relationship, Drug</subject><subject>General pharmacology</subject><subject>Glioma</subject><subject>Inhibitory Concentration 50</subject><subject>Macrophages - drug effects</subject><subject>Marine</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Molecular Conformation</subject><subject>Molecular Structure</subject><subject>natural products</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plakinamine G</subject><subject>plakinamine H</subject><subject>Porifera - chemistry</subject><subject>Rats</subject><subject>steroidal alkaloids</subject><subject>Steroids - chemistry</subject><subject>Steroids - isolation & purification</subject><subject>Steroids - pharmacology</subject><subject>tetrahydroplakinamine A</subject><subject>Vanuatu</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0MtKw0AUBuBBFK2XhS8g2Si4SD1zn2yEUi8VFMUqLodpOtFpk0ycSUDf3kiL3bg6B87Hz-FH6BjDEAPBF3UDBIDIsIUGmBNIBRC-jQaABU2pEmwP7ce4AAAKGd9Fe5jgjALlA3T54Gofkmlrg3dzUyajcmnKfo1JEXyVtB82eTDB1TaZNr5-t8nYh9blrquS2AwP0U5hymiP1vMAvd5cv4wn6f3j7d14dJ8ahqFNRcEJNUQRjBWHgkpB7dxioxRjc8sZWCmFmRGSESAKZzIHyUBJovIZMCroATpb5TbBf3Y2trpyMbdlaWrru6ixUpwxkfXwfAXz4GMMttBNcJUJ3xqD_i1L_5XV25N1aDer7Hwj1-304HQNTMxNWQRT5y5uHFUKVMZ6l66ci639-rubsNRCUsn1y9NUy-crNZ7wN002uSaPeuG7UPfd_fPgDxmViTs</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Borbone, Nicola</creator><creator>De Marino, Simona</creator><creator>Iorizzi, Maria</creator><creator>Zollo, Franco</creator><creator>Debitus, Cecile</creator><creator>Esposito, Giuseppe</creator><creator>Iuvone, Teresa</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope></search><sort><creationdate>20020801</creationdate><title>Minor Steroidal Alkaloids from the Marine Sponge Corticium sp.</title><author>Borbone, Nicola ; De Marino, Simona ; Iorizzi, Maria ; Zollo, Franco ; Debitus, Cecile ; Esposito, Giuseppe ; Iuvone, Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a410t-6f523a28211850f3763ede1a8844de540e776ab2292028197c07408728cb04363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>4 alpha -hydroxydemethylplakinamine B</topic><topic>Alkaloids - chemistry</topic><topic>Alkaloids - isolation & purification</topic><topic>Alkaloids - pharmacology</topic><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured - drug effects</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Corticium</topic><topic>Dose-Response Relationship, Drug</topic><topic>General pharmacology</topic><topic>Glioma</topic><topic>Inhibitory Concentration 50</topic><topic>Macrophages - drug effects</topic><topic>Marine</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Molecular Conformation</topic><topic>Molecular Structure</topic><topic>natural products</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plakinamine G</topic><topic>plakinamine H</topic><topic>Porifera - chemistry</topic><topic>Rats</topic><topic>steroidal alkaloids</topic><topic>Steroids - chemistry</topic><topic>Steroids - isolation & purification</topic><topic>Steroids - pharmacology</topic><topic>tetrahydroplakinamine A</topic><topic>Vanuatu</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borbone, Nicola</creatorcontrib><creatorcontrib>De Marino, Simona</creatorcontrib><creatorcontrib>Iorizzi, Maria</creatorcontrib><creatorcontrib>Zollo, Franco</creatorcontrib><creatorcontrib>Debitus, Cecile</creatorcontrib><creatorcontrib>Esposito, Giuseppe</creatorcontrib><creatorcontrib>Iuvone, Teresa</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borbone, Nicola</au><au>De Marino, Simona</au><au>Iorizzi, Maria</au><au>Zollo, Franco</au><au>Debitus, Cecile</au><au>Esposito, Giuseppe</au><au>Iuvone, Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minor Steroidal Alkaloids from the Marine Sponge Corticium sp.</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>65</volume><issue>8</issue><spage>1206</spage><epage>1209</epage><pages>1206-1209</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Four new steroidal alkaloids, plakinamine G (1), plakinamine H (2), 4α-hydroxydemethylplakinamine B (3), and tetrahydroplakinamine A (4), along with three known compounds, were isolated from the marine sponge Corticium sp. The structures of these metabolites were elucidated largely by 1D and 2D NMR methods and accurate mass measurements (HR-EIMS). Compounds 1, 2, and 4 show significant in vitro cytotoxicity.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>12193035</pmid><doi>10.1021/np020027r</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of natural products (Washington, D.C.), 2002-08, Vol.65 (8), p.1206-1209 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | 4 alpha -hydroxydemethylplakinamine B Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Cells, Cultured - drug effects Chromatography, High Pressure Liquid Corticium Dose-Response Relationship, Drug General pharmacology Glioma Inhibitory Concentration 50 Macrophages - drug effects Marine Medical sciences Mice Molecular Conformation Molecular Structure natural products Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plakinamine G plakinamine H Porifera - chemistry Rats steroidal alkaloids Steroids - chemistry Steroids - isolation & purification Steroids - pharmacology tetrahydroplakinamine A Vanuatu |
| title | Minor Steroidal Alkaloids from the Marine Sponge Corticium sp. |
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