Minor Steroidal Alkaloids from the Marine Sponge Corticium sp.

Four new steroidal alkaloids, plakinamine G (1), plakinamine H (2), 4α-hydroxydemethylplakinamine B (3), and tetrahydroplakinamine A (4), along with three known compounds, were isolated from the marine sponge Corticium sp. The structures of these metabolites were elucidated largely by 1D and 2D NMR...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2002-08, Vol.65 (8), p.1206-1209
Hauptverfasser:	Borbone, Nicola, De Marino, Simona, Iorizzi, Maria, Zollo, Franco, Debitus, Cecile, Esposito, Giuseppe, Iuvone, Teresa
Format:	Artikel
Sprache:	eng
Schlagworte:	4 alpha -hydroxydemethylplakinamine B Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Cells, Cultured - drug effects Chromatography, High Pressure Liquid Corticium Dose-Response Relationship, Drug General pharmacology Glioma Inhibitory Concentration 50 Macrophages - drug effects Marine Medical sciences Mice Molecular Conformation Molecular Structure natural products Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plakinamine G plakinamine H Porifera - chemistry Rats steroidal alkaloids Steroids - chemistry Steroids - isolation & purification Steroids - pharmacology tetrahydroplakinamine A Vanuatu
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Beschreibung
Zusammenfassung:	Four new steroidal alkaloids, plakinamine G (1), plakinamine H (2), 4α-hydroxydemethylplakinamine B (3), and tetrahydroplakinamine A (4), along with three known compounds, were isolated from the marine sponge Corticium sp. The structures of these metabolites were elucidated largely by 1D and 2D NMR methods and accurate mass measurements (HR-EIMS). Compounds 1, 2, and 4 show significant in vitro cytotoxicity.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np020027r