Neuropsychiatric symptoms in Alzheimer's disease: associations with caregiver burden and treatment outcomes

Caregivers play a major role in providing care for patients with Alzheimer's disease (AD) and are themselves at higher risk of health comorbidities. To address the impact of neuropsychiatric symptoms of patients in different stages of AD on their caregivers' burden. This prospective study...

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Veröffentlicht in:	QJM : An International Journal of Medicine 2017-09, Vol.110 (9), p.565-570
Hauptverfasser:	Chen, C T, Chang, C-C, Chang, W-N, Tsai, N-W, Huang, C-C, Chang, Y-T, Wang, H-C, Kung, C-T, Su, Y-J, Lin, W-C, Cheng, B-C, Su, C-M, Hsiao, S-Y, Hsu, C-W, Lu, C-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Psychological Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - psychology Alzheimer Disease - therapy Behavioral Symptoms - diagnosis Behavioral Symptoms - etiology Behavioral Symptoms - therapy Caregivers - psychology China Cognition Cost of Illness Female Humans Male Mental Competency - psychology Middle Aged Neuropsychological Tests Nootropic Agents - therapeutic use Prospective Studies Psychiatric Status Rating Scales Quality of Life Treatment Outcome
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Zusammenfassung:	Caregivers play a major role in providing care for patients with Alzheimer's disease (AD) and are themselves at higher risk of health comorbidities. To address the impact of neuropsychiatric symptoms of patients in different stages of AD on their caregivers' burden. This prospective study enrolled 260 AD patients with clinical dementia rating (CDR) of 0.5, 1 and 2 at a tertiary medical center. All patients were tested using the mini-mental state examination (MMSE), the cognitive abilities screening instrument (CASI), the neuropsychiatric inventory (NPI) and the CDR scale. Data regarding therapeutic outcomes of anti-Alzheimer's drugs were also collected. Caregivers were tested using NPI. The mean follow-up interval was 25.0 ± 12.2 months, and two patients died during follow-up. NPI-burden was positively correlated with NPI-sum ( r = 0.822, P < 0.001) but negatively correlated with years of education ( r = -0.140, P = 0.024), CASI score ( r = -0.259, P < 0.001) and MMSE score ( r = -0.262, P
ISSN:	1460-2725 1460-2393
DOI:	10.1093/qjmed/hcx077