Ovarian tissue cryopreservation in female-to-male transgender people: insights into ovarian histology and physiology after prolonged androgen treatment

Highlights • Cortical follicle distribution seems surprisingly normal after more than a year of testosterone treatment. • The cumulus-oocyte complex (COC) yield can be predicted based on AMH serum levels. • COC are present and in vitro maturation is possible after androgen therapy. • Combined freezi...

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Veröffentlicht in:	Reproductive biomedicine online 2017-06, Vol.34 (6), p.557-566
Hauptverfasser:	De Roo, C, Lierman, S, Tilleman, K, Peynshaert, K, Braeckmans, K, Caanen, M, Lambalk, CB, Weyers, S, T'Sjoen, G, Cornelissen, R, De Sutter, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Androgens - pharmacology Anti-Müllerian hormone Cryopreservation Cumulus-oocyte complex Female Fertility preservation Hormones - blood Humans In vitro maturation In Vitro Oocyte Maturation Techniques Male Obstetrics and Gynecology Ovarian tissue Ovary - anatomy & histology Ovary - drug effects Prospective Studies Testosterone - pharmacology Transgender Persons Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Cortical follicle distribution seems surprisingly normal after more than a year of testosterone treatment. • The cumulus-oocyte complex (COC) yield can be predicted based on AMH serum levels. • COC are present and in vitro maturation is possible after androgen therapy. • Combined freezing of cortex and in vitro matured COC may optimize fertility potential.
ISSN:	1472-6483 1472-6491
DOI:	10.1016/j.rbmo.2017.03.008