Neuroprotective effect of cerium oxide nanoparticles in a rat model of experimental diabetic neuropathy

Highlights • CeO2 nanoparticles increased body weight, total thiol molecules, total antioxidant power and ADP/ATP ratio in diabetic rat. • CeO2 nanoparticles decreased lipid peroxidation and nociception latency in STZ-treated rats. • CeO2 nanoparticles improved the histopathology and morphological a...

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Veröffentlicht in:	Brain research bulletin 2017-05, Vol.131, p.117-122
Hauptverfasser:	Najafi, Rezvan, Hosseini, Asieh, Ghaznavi, Habib, Mehrzadi, Saeed, Sharifi, Ali M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Blood Glucose - drug effects Body Weight - drug effects CeO2 nanoparticles Cerium - pharmacology Cerium - therapeutic use Diabetes Mellitus, Experimental - drug therapy Diabetic Neuropathies - drug therapy Diabetic neuropathy Disease Models, Animal Dorsal root ganglion Ganglia, Spinal - drug effects High glucose Lipid Peroxidation - drug effects Male Nanoparticles - therapeutic use Neurology Neurons - drug effects Neuroprotective Agents - pharmacology Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Sulfhydryl Compounds
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Beschreibung
Zusammenfassung:	Highlights • CeO2 nanoparticles increased body weight, total thiol molecules, total antioxidant power and ADP/ATP ratio in diabetic rat. • CeO2 nanoparticles decreased lipid peroxidation and nociception latency in STZ-treated rats. • CeO2 nanoparticles improved the histopathology and morphological abnormalities of DRG neurons.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2017.03.013