Paediatric systemic lupus erythematosus: insights from translational research

Investigations in paediatric SLE contributed significantly to the discovery of the association of type I IFNs with lupus and underscored the potential application of this knowledge by informing the use of glucocorticoid therapy. Recent, promising research reveals biomarkers that may yield more focus...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2017-04, Vol.56 (suppl_1), p.i24-i31
Hauptverfasser:	Wright, Tracey B, Punaro, Marilynn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age of Onset Biomarkers Child Glucocorticoids - therapeutic use Humans Interferon Type I - immunology Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - physiopathology Translational Medical Research
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Beschreibung
Zusammenfassung:	Investigations in paediatric SLE contributed significantly to the discovery of the association of type I IFNs with lupus and underscored the potential application of this knowledge by informing the use of glucocorticoid therapy. Recent, promising research reveals biomarkers that may yield more focused clinical monitoring and assessment of response to treatment. This article reviews unique features of paediatric SLE and details important developments in paediatric lupus research.
ISSN:	1462-0324 1462-0332
DOI:	10.1093/rheumatology/kew447