Synchronized Chiral Induction between [5]Helicene–Spermine Ligand and B–Z DNA Transition

The 2,13‐dimethoxy[5]helicene–spermine ligand 8 b possesses an axial chirality. The racemic 8 b was bound to B‐DNA by the accompanying induction of its (P)‐chirality together with the B‐to‐Z helicity change of the duplex DNA, [(dC‐dG)3]2. The (P)‐chirality of the bound 8 b, in turn, transitioned to the (M)‐chirality according to the Z‐helicity of the DNA. These results illustrate the chirality synchronization between the DNA and the ligand. Let′s twist again! The 2,13‐dimethoxy[5]helicene–spermine ligand 8 b possesses an axial chirality. The racemic 8 b was bound to B‐DNA with accompanying induction of its (P)‐chirality together with the B‐to‐Z helicity change of the duplex DNA, [(dC‐dG)3]2. The (P)‐chirality of the bound 8 b, in turn, transitioned to the (M)‐chirality according to the Z‐helicity of DNA. These results have illustrated the chirality synchronization between the DNA and ligand.