Activatable Photoacoustic Nanoprobes for In Vivo Ratiometric Imaging of Peroxynitrite

Activatable Photoacoustic Nanoprobes for In Vivo Ratiometric Imaging of Peroxynitrite

Organic semiconducting nanoprobes doped with bulky borane can undergo specific activation by ONOO− even at tumor‐relevant acidic pH (6.8), permitting in vivo ratiometric photoacoustic imaging of ONOO− in the tumor environment of living mice.

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Veröffentlicht in:Advanced materials (Weinheim) 2017-02, Vol.29 (6), p.np-n/a
Hauptverfasser: Zhang, Jianjian, Zhen, Xu, Upputuri, Paul Kumar, Pramanik, Manojit, Chen, Peng, Pu, Kanyi
Format: Artikel
Sprache:eng
Schlagworte:
activatable probes
Activation
Boranes
Imaging
Materials science
Mice
nanoprobes
Nanostructure
peroxynitrite
photoacoustic imaging
Tumors
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Beschreibung
Zusammenfassung:Organic semiconducting nanoprobes doped with bulky borane can undergo specific activation by ONOO− even at tumor‐relevant acidic pH (6.8), permitting in vivo ratiometric photoacoustic imaging of ONOO− in the tumor environment of living mice.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201604764