A bioorthogonal 'turn-on' fluorescent probe for tracking mitochondrial nitroxyl formation

A bioorthogonal 'turn-on' fluorescent probe for tracking mitochondrial nitroxyl formation

A bioreductant-resistant 'turn-on' chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formati...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017-02, Vol.53 (10), p.1723-1726
Hauptverfasser: Sunwoo, Kyoung, Bobba, Kondapa Naidu, Lim, Ja-Yun, Park, Taegun, Podder, Arup, Heo, June Seok, Lee, Seung Gwan, Bhuniya, Sankarprasad, Kim, Jong Seung
Format: Artikel
Sprache:eng
Schlagworte:
Fluorescence
Formations
Image detection
Imaging
Tracking
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Zusammenfassung:A bioreductant-resistant 'turn-on' chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc09082f