Ir-catalyzed asymmetric hydrogenation of β-keto esters with chiral ferrocenyl P,N,N-ligands

Ir-catalyzed asymmetric hydrogenation of β-keto esters with chiral ferrocenyl P,N,N-ligands

The Ir-catalyzed asymmetric hydrogenation of β-keto esters with chiral ferrocenyl P,N,N-ligands has been developed. Under the optimized conditions, a wide range of β-keto esters were hydrogenated to afford the corresponding β-hydroxy esters in good to excellent enantioselectivities (up to 95% ee)....

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Veröffentlicht in:RSC advances 2017-01, Vol.7 (21), p.12871-12875
Hauptverfasser: Chen, Xiu-Shuai, Hou, Chuan-Jin, Qin, Chao, Liu, Hongzhu, Liu, Yan-Jun, Huang, De-Zhi, Hu, Xiang-Ping
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetry
Esters
Hydrogenation
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Zusammenfassung:The Ir-catalyzed asymmetric hydrogenation of β-keto esters with chiral ferrocenyl P,N,N-ligands has been developed. Under the optimized conditions, a wide range of β-keto esters were hydrogenated to afford the corresponding β-hydroxy esters in good to excellent enantioselectivities (up to 95% ee).
ISSN:2046-2069
2046-2069
DOI:10.1039/C7RA00472A