Relevance of focal osseous uptake on FDG PET with or without CT changes in oncology patients

Abstract Objective To assess significance of focal FDG uptake in osseous structures, with and without CT correlate, in patients undergoing FDG PET/CT for oncological indications. Methods 57 patients with focally increased FDG activity in bones and a definite follow up were included. Results 82.5% of lesions without changes were found to be malignant. Sensitivity and PPV of a CT correlate in metastatic lesions was expectedly high, 62.9% and 86.7% respectively, however, the NPV was only 14.8%. Conclusion Osseous foci are valuable in predicting metastatic disease even in the absence of low dose CT correlate.