Emergence through delicate balance between the steric factor and molecular orientation: a highly bright and photostable DNA marker for real-time monitoring of cell growth dynamics
Due to its remarkable structural and optical stability in biological milieu, a newly developed small molecule based DNA marker with high brightness (Φ = 0.51, brightness = 26 300 M cm ) and almost zero toxicity has been explored. For the first time to our knowledge, this approach has provided real-t...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2017-02, Vol.53 (17), p.2571-2574 |
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| container_end_page | 2574 |
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| container_issue | 17 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 53 |
| creator | Gaur, Pankaj Kumar, Ajay Dalal, Reena Bhattacharyya, Shalmoli Ghosh, Subrata |
| description | Due to its remarkable structural and optical stability in biological milieu, a newly developed small molecule based DNA marker with high brightness (Φ = 0.51, brightness = 26 300 M
cm
) and almost zero toxicity has been explored. For the first time to our knowledge, this approach has provided real-time monitoring of growth and reproductive potency of living cells beyond nine days. |
| doi_str_mv | 10.1039/c6cc09355h |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2017-02, Vol.53 (17), p.2571-2574 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1884108975 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biomarkers - chemistry Brightness Cell Proliferation Cells (biology) Deoxyribonucleic acid DNA - chemistry Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry HeLa Cells Humans Markers Molecular Structure Monitoring Orientation Photochemical Processes Real time Structural stability Time Factors |
| title | Emergence through delicate balance between the steric factor and molecular orientation: a highly bright and photostable DNA marker for real-time monitoring of cell growth dynamics |
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