Emergence through delicate balance between the steric factor and molecular orientation: a highly bright and photostable DNA marker for real-time monitoring of cell growth dynamics

Emergence through delicate balance between the steric factor and molecular orientation: a highly bright and photostable DNA marker for real-time monitoring of cell growth dynamics

Due to its remarkable structural and optical stability in biological milieu, a newly developed small molecule based DNA marker with high brightness (Φ = 0.51, brightness = 26 300 M cm ) and almost zero toxicity has been explored. For the first time to our knowledge, this approach has provided real-t...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017-02, Vol.53 (17), p.2571-2574
Hauptverfasser: Gaur, Pankaj, Kumar, Ajay, Dalal, Reena, Bhattacharyya, Shalmoli, Ghosh, Subrata
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers - chemistry
Brightness
Cell Proliferation
Cells (biology)
Deoxyribonucleic acid
DNA - chemistry
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Markers
Molecular Structure
Monitoring
Orientation
Photochemical Processes
Real time
Structural stability
Time Factors
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Beschreibung
Zusammenfassung:Due to its remarkable structural and optical stability in biological milieu, a newly developed small molecule based DNA marker with high brightness (Φ = 0.51, brightness = 26 300 M cm ) and almost zero toxicity has been explored. For the first time to our knowledge, this approach has provided real-time monitoring of growth and reproductive potency of living cells beyond nine days.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc09355h