AAZTA: An Ideal Chelating Agent for the Development of super(44)Sc PET Imaging Agents

Unprecedented fast and efficient complexation of Sc super(III) was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methyl p erhydro-1,4-diazepine) under mild experimental conditions. The robustness of the super(44)Sc(AAZTA) super(-) chelate and conjugated biomolecules thereof is further shown by invivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.Original Abstract: AAZTA (1,4-Bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhyd r o-1,4-diazepin) ist ein vielversprechender Chelatligand fuer Scandium-Radiopharmaka, der thermodynamisch hoch stabile, kinetisch inerte und sich schnell bildende Komplexe liefert. AAZTA ermoglicht die Herstellung super(44)Sc-radiomarkierter (Bio)Konjugate unter milden Bedingungen dank der langen Lebensdauer des super(44)Sc-Isotops (RCY=radiochemische Ausbeute).