One-pot native chemical ligation by combination of two orthogonal thioester precursors

One-pot native chemical ligation by combination of two orthogonal thioester precursors

We developed a one-pot peptide ligation method using two orthogonal thioester precursors and a protecting group for the ligation reaction between Asp and Cys. Combination of the two precursors facilitated the one-pot operation and yielded the entire polypeptide. The usefulness of this method was suc...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (13), p.2114-2117
Hauptverfasser: Asahina, Yuya, Kawakami, Toru, Hojo, Hironobu
Format: Artikel
Sprache:eng
Schlagworte:
Group dynamics
Histones
Peptides
Polypeptides
Precursors
Synthesis
Thioesters
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Beschreibung
Zusammenfassung:We developed a one-pot peptide ligation method using two orthogonal thioester precursors and a protecting group for the ligation reaction between Asp and Cys. Combination of the two precursors facilitated the one-pot operation and yielded the entire polypeptide. The usefulness of this method was successfully demonstrated by the total synthesis of histone H4.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc10243c