Regioselective copper-diamine-catalyzed C-H arylation of 1,2,4-triazole ring with aryl bromides

A convenient methodology for the regioselective C-H arylation of 1,2,4-triazole ring was developed. Using a benchtop stable Cu-diamine catalyst system, C-H functionalization of a simple 1,2,4-triazole substrate with various aryl bromides was regioselectively accomplished at the C5 position of the triazole ring. A bench-top protocol using simple Cu-diamine catalysis for the regioselective C5-H arylation of 1,2,4-triazole ring with (hetero)aryl bromides.