First report on bio-catalytic N-formylation of amines using ethyl formate

A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate as a formylating agent. This protocol provides a facile and convenient strategy featuring mild reaction conditions, high efficacy, a broad substrate scope and recyclability of lipase. This method also w...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (15), p.2382-2385
Hauptverfasser: Patre, Rupesh E, Mal, Sanjib, Nilkanth, Pankaj R, Ghorai, Sujit K, Deshpande, Sudhindra H, El Qacemi, Myriem, Smejkal, Tomas, Pal, Sitaram, Manjunath, Bhanu N
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container_title Chemical communications (Cambridge, England)
container_volume 53
creator Patre, Rupesh E
Mal, Sanjib
Nilkanth, Pankaj R
Ghorai, Sujit K
Deshpande, Sudhindra H
El Qacemi, Myriem
Smejkal, Tomas
Pal, Sitaram
Manjunath, Bhanu N
description A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate as a formylating agent. This protocol provides a facile and convenient strategy featuring mild reaction conditions, high efficacy, a broad substrate scope and recyclability of lipase. This method also works on a large scale in high yield.
doi_str_mv 10.1039/c6cc07679c
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Amines
Effectiveness
Formates
Lipase
Recyclability
Strategy
Substrates
title First report on bio-catalytic N-formylation of amines using ethyl formate
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