Vitamin D deficiency is associated with digital ulcer but not with atherosclerosis or arterial stiffness in patients with systemic sclerosis: a pilot study
The objective of this study was to investigate the association of vitamin D deficiency with digital ulcers (DUs) that result from microvasculopathy, carotid intima-media thickness (CIMT) as surrogate markers of atherosclerosis, and brachial-ankle pulse wave velocity (baPWV) representing arterial sti...
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| Veröffentlicht in: | Clinical rheumatology 2017-06, Vol.36 (6), p.1325-1333 |
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| creator | Park, Eun-Kyoung Park, Ji-Heh Kweon, Seong-Min Kim, Geun-Tae Lee, Seung-Geun |
| description | The objective of this study was to investigate the association of vitamin D deficiency with digital ulcers (DUs) that result from microvasculopathy, carotid intima-media thickness (CIMT) as surrogate markers of atherosclerosis, and brachial-ankle pulse wave velocity (baPWV) representing arterial stiffness in patients with systemic sclerosis (SSc). In this cross-sectional study, 40 female SSc patients and 80 healthy controls matched for sex, age, and blood sampling season were recruited. Vitamin D deficiency was defined as serum 25-OHD levels |
| doi_str_mv | 10.1007/s10067-017-3622-9 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1883840645</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1883840645</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-7cda0a9adb317c1720711b6464e329e6d5e1b832581db6902b021eefb257078c3</originalsourceid><addsrcrecordid>eNp1kctqFUEQhhsxmGP0AdxIgxs3o32Z6Ys7iVcIZBPdNj3dNUmHuRy7egjnWXzZ9GFiEMFN1aK-_68qfkJecfaOM6bfY61KN4zrRiohGvuE7Hgr28ba1j4lO6Y1ayS35pQ8R7xljAlj-TNyKoxUnWFqR37_TMVPaaafaIQhhQRzONCE1CMuIfkCkd6lckNjuq7kSNcxQKb9Wui8lG3kyw3kBcN4rFW6ZOpzgZwqjiUNwwyItO7Y-1L9C24yPGCBKQX6qPxAPd2nsfpiWePhBTkZ_Ijw8qGfkR9fPl-df2suLr9-P_940QSpRWl0iJ5562MvuQ5cC6Y571WrWpDCgood8N5I0Rkee2WZ6JngAEMvOs20CfKMvN1893n5tQIWNyUMMI5-hmVFx42RpmWq7Sr65h_0dlnzXK9z3LJWa2msqRTfqFDfwgyD2-c0-XxwnLljcm5LztXk3DE5Z6vm9YPz2k8QHxV_oqqA2ACso_ka8l-r_-t6DwgopjQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1904773898</pqid></control><display><type>article</type><title>Vitamin D deficiency is associated with digital ulcer but not with atherosclerosis or arterial stiffness in patients with systemic sclerosis: a pilot study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Park, Eun-Kyoung ; Park, Ji-Heh ; Kweon, Seong-Min ; Kim, Geun-Tae ; Lee, Seung-Geun</creator><creatorcontrib>Park, Eun-Kyoung ; Park, Ji-Heh ; Kweon, Seong-Min ; Kim, Geun-Tae ; Lee, Seung-Geun</creatorcontrib><description>The objective of this study was to investigate the association of vitamin D deficiency with digital ulcers (DUs) that result from microvasculopathy, carotid intima-media thickness (CIMT) as surrogate markers of atherosclerosis, and brachial-ankle pulse wave velocity (baPWV) representing arterial stiffness in patients with systemic sclerosis (SSc). In this cross-sectional study, 40 female SSc patients and 80 healthy controls matched for sex, age, and blood sampling season were recruited. Vitamin D deficiency was defined as serum 25-OHD levels <30 ng/mL. “DUs ever” included active and healed DUs. CIMT and carotid plaque were examined using high-resolution ultrasonography, and baPWV was measured using an automatic waveform analyzer. Vitamin D deficiency was more prevalent in SSc patients than in controls (30 vs. 11.3%). Regarding SSc patients, 9 (22.5%) had DUs ever, and the mean CIMT and baPWV were 0.68 mm and 1561.1 cm/s, respectively; carotid plaque was detected in 13 (34.2%) patients. The frequency of DUs ever was significantly higher for SSc patients with vitamin D deficiency than those without this feature (50 vs. 10.7%,
p
= 0.012), but the median CIMT and baPWV and the frequency of carotid plaque did not differ according to the presence of vitamin D deficiency. Multivariable logistic regression analysis showed that vitamin D deficiency was an independent risk factor for DUs ever (OR = 7.72,
p
= 0.024). Vitamin D deficiency was associated with DUs, but not with atherosclerosis or arterial stiffness, potentially indicating that vitamin D may have different effects on the microvascular and macrovascular involvement in SSc pathophysiology.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-017-3622-9</identifier><identifier>PMID: 28365806</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Aged ; Ankle ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - blood ; Atherosclerosis - diagnostic imaging ; Atherosclerosis - etiology ; Carotid Intima-Media Thickness ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Humans ; Medicine ; Medicine & Public Health ; Microvasculature ; Middle Aged ; Original Article ; Pilot Projects ; Pulse Wave Analysis ; Rheumatology ; Scleroderma ; Scleroderma, Systemic - blood ; Scleroderma, Systemic - complications ; Scleroderma, Systemic - diagnostic imaging ; Skin Ulcer - blood ; Skin Ulcer - etiology ; Systemic sclerosis ; Ulcers ; Ultrasound ; Vascular Stiffness ; Velocity ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - complications ; Vitamin deficiency</subject><ispartof>Clinical rheumatology, 2017-06, Vol.36 (6), p.1325-1333</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2017</rights><rights>Clinical Rheumatology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-7cda0a9adb317c1720711b6464e329e6d5e1b832581db6902b021eefb257078c3</citedby><cites>FETCH-LOGICAL-c372t-7cda0a9adb317c1720711b6464e329e6d5e1b832581db6902b021eefb257078c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-017-3622-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-017-3622-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28365806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Eun-Kyoung</creatorcontrib><creatorcontrib>Park, Ji-Heh</creatorcontrib><creatorcontrib>Kweon, Seong-Min</creatorcontrib><creatorcontrib>Kim, Geun-Tae</creatorcontrib><creatorcontrib>Lee, Seung-Geun</creatorcontrib><title>Vitamin D deficiency is associated with digital ulcer but not with atherosclerosis or arterial stiffness in patients with systemic sclerosis: a pilot study</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>The objective of this study was to investigate the association of vitamin D deficiency with digital ulcers (DUs) that result from microvasculopathy, carotid intima-media thickness (CIMT) as surrogate markers of atherosclerosis, and brachial-ankle pulse wave velocity (baPWV) representing arterial stiffness in patients with systemic sclerosis (SSc). In this cross-sectional study, 40 female SSc patients and 80 healthy controls matched for sex, age, and blood sampling season were recruited. Vitamin D deficiency was defined as serum 25-OHD levels <30 ng/mL. “DUs ever” included active and healed DUs. CIMT and carotid plaque were examined using high-resolution ultrasonography, and baPWV was measured using an automatic waveform analyzer. Vitamin D deficiency was more prevalent in SSc patients than in controls (30 vs. 11.3%). Regarding SSc patients, 9 (22.5%) had DUs ever, and the mean CIMT and baPWV were 0.68 mm and 1561.1 cm/s, respectively; carotid plaque was detected in 13 (34.2%) patients. The frequency of DUs ever was significantly higher for SSc patients with vitamin D deficiency than those without this feature (50 vs. 10.7%,
p
= 0.012), but the median CIMT and baPWV and the frequency of carotid plaque did not differ according to the presence of vitamin D deficiency. Multivariable logistic regression analysis showed that vitamin D deficiency was an independent risk factor for DUs ever (OR = 7.72,
p
= 0.024). Vitamin D deficiency was associated with DUs, but not with atherosclerosis or arterial stiffness, potentially indicating that vitamin D may have different effects on the microvascular and macrovascular involvement in SSc pathophysiology.</description><subject>Aged</subject><subject>Ankle</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Atherosclerosis - etiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Pilot Projects</subject><subject>Pulse Wave Analysis</subject><subject>Rheumatology</subject><subject>Scleroderma</subject><subject>Scleroderma, Systemic - blood</subject><subject>Scleroderma, Systemic - complications</subject><subject>Scleroderma, Systemic - diagnostic imaging</subject><subject>Skin Ulcer - blood</subject><subject>Skin Ulcer - etiology</subject><subject>Systemic sclerosis</subject><subject>Ulcers</subject><subject>Ultrasound</subject><subject>Vascular Stiffness</subject><subject>Velocity</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin deficiency</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kctqFUEQhhsxmGP0AdxIgxs3o32Z6Ys7iVcIZBPdNj3dNUmHuRy7egjnWXzZ9GFiEMFN1aK-_68qfkJecfaOM6bfY61KN4zrRiohGvuE7Hgr28ba1j4lO6Y1ayS35pQ8R7xljAlj-TNyKoxUnWFqR37_TMVPaaafaIQhhQRzONCE1CMuIfkCkd6lckNjuq7kSNcxQKb9Wui8lG3kyw3kBcN4rFW6ZOpzgZwqjiUNwwyItO7Y-1L9C24yPGCBKQX6qPxAPd2nsfpiWePhBTkZ_Ijw8qGfkR9fPl-df2suLr9-P_940QSpRWl0iJ5562MvuQ5cC6Y571WrWpDCgood8N5I0Rkee2WZ6JngAEMvOs20CfKMvN1893n5tQIWNyUMMI5-hmVFx42RpmWq7Sr65h_0dlnzXK9z3LJWa2msqRTfqFDfwgyD2-c0-XxwnLljcm5LztXk3DE5Z6vm9YPz2k8QHxV_oqqA2ACso_ka8l-r_-t6DwgopjQ</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Park, Eun-Kyoung</creator><creator>Park, Ji-Heh</creator><creator>Kweon, Seong-Min</creator><creator>Kim, Geun-Tae</creator><creator>Lee, Seung-Geun</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Vitamin D deficiency is associated with digital ulcer but not with atherosclerosis or arterial stiffness in patients with systemic sclerosis: a pilot study</title><author>Park, Eun-Kyoung ; Park, Ji-Heh ; Kweon, Seong-Min ; Kim, Geun-Tae ; Lee, Seung-Geun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-7cda0a9adb317c1720711b6464e329e6d5e1b832581db6902b021eefb257078c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Ankle</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Atherosclerosis - etiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microvasculature</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Pilot Projects</topic><topic>Pulse Wave Analysis</topic><topic>Rheumatology</topic><topic>Scleroderma</topic><topic>Scleroderma, Systemic - blood</topic><topic>Scleroderma, Systemic - complications</topic><topic>Scleroderma, Systemic - diagnostic imaging</topic><topic>Skin Ulcer - blood</topic><topic>Skin Ulcer - etiology</topic><topic>Systemic sclerosis</topic><topic>Ulcers</topic><topic>Ultrasound</topic><topic>Vascular Stiffness</topic><topic>Velocity</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Eun-Kyoung</creatorcontrib><creatorcontrib>Park, Ji-Heh</creatorcontrib><creatorcontrib>Kweon, Seong-Min</creatorcontrib><creatorcontrib>Kim, Geun-Tae</creatorcontrib><creatorcontrib>Lee, Seung-Geun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Eun-Kyoung</au><au>Park, Ji-Heh</au><au>Kweon, Seong-Min</au><au>Kim, Geun-Tae</au><au>Lee, Seung-Geun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D deficiency is associated with digital ulcer but not with atherosclerosis or arterial stiffness in patients with systemic sclerosis: a pilot study</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>36</volume><issue>6</issue><spage>1325</spage><epage>1333</epage><pages>1325-1333</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>The objective of this study was to investigate the association of vitamin D deficiency with digital ulcers (DUs) that result from microvasculopathy, carotid intima-media thickness (CIMT) as surrogate markers of atherosclerosis, and brachial-ankle pulse wave velocity (baPWV) representing arterial stiffness in patients with systemic sclerosis (SSc). In this cross-sectional study, 40 female SSc patients and 80 healthy controls matched for sex, age, and blood sampling season were recruited. Vitamin D deficiency was defined as serum 25-OHD levels <30 ng/mL. “DUs ever” included active and healed DUs. CIMT and carotid plaque were examined using high-resolution ultrasonography, and baPWV was measured using an automatic waveform analyzer. Vitamin D deficiency was more prevalent in SSc patients than in controls (30 vs. 11.3%). Regarding SSc patients, 9 (22.5%) had DUs ever, and the mean CIMT and baPWV were 0.68 mm and 1561.1 cm/s, respectively; carotid plaque was detected in 13 (34.2%) patients. The frequency of DUs ever was significantly higher for SSc patients with vitamin D deficiency than those without this feature (50 vs. 10.7%,
p
= 0.012), but the median CIMT and baPWV and the frequency of carotid plaque did not differ according to the presence of vitamin D deficiency. Multivariable logistic regression analysis showed that vitamin D deficiency was an independent risk factor for DUs ever (OR = 7.72,
p
= 0.024). Vitamin D deficiency was associated with DUs, but not with atherosclerosis or arterial stiffness, potentially indicating that vitamin D may have different effects on the microvascular and macrovascular involvement in SSc pathophysiology.</abstract><cop>London</cop><pub>Springer London</pub><pmid>28365806</pmid><doi>10.1007/s10067-017-3622-9</doi><tpages>9</tpages></addata></record> |
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| ispartof | Clinical rheumatology, 2017-06, Vol.36 (6), p.1325-1333 |
| issn | 0770-3198 1434-9949 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Ankle Arteriosclerosis Atherosclerosis Atherosclerosis - blood Atherosclerosis - diagnostic imaging Atherosclerosis - etiology Carotid Intima-Media Thickness Case-Control Studies Cross-Sectional Studies Female Humans Medicine Medicine & Public Health Microvasculature Middle Aged Original Article Pilot Projects Pulse Wave Analysis Rheumatology Scleroderma Scleroderma, Systemic - blood Scleroderma, Systemic - complications Scleroderma, Systemic - diagnostic imaging Skin Ulcer - blood Skin Ulcer - etiology Systemic sclerosis Ulcers Ultrasound Vascular Stiffness Velocity Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - complications Vitamin deficiency |
| title | Vitamin D deficiency is associated with digital ulcer but not with atherosclerosis or arterial stiffness in patients with systemic sclerosis: a pilot study |
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