Ferroptosis Inhibition: Mechanisms and Opportunities
The past decade has yielded tremendous insights into how cells die. This has come with our understanding that several distinct forms of cell death are encompassed under the umbrella term necrosis. Among these distinct forms of regulated necrotic cell death, ferroptosis has attracted considerable att...
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Veröffentlicht in: | Trends in pharmacological sciences (Regular ed.) 2017-05, Vol.38 (5), p.489-498 |
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creator | Angeli, Jose Pedro Friedmann Shah, Ron Pratt, Derek A Conrad, Marcus |
description | The past decade has yielded tremendous insights into how cells die. This has come with our understanding that several distinct forms of cell death are encompassed under the umbrella term necrosis. Among these distinct forms of regulated necrotic cell death, ferroptosis has attracted considerable attention owing to its putative involvement in diverse pathophysiological processes. A key feature of the ferroptosis process is the requirement of phospholipid peroxidation, a process that has been linked with several human pathologies. Now with the establishment of a connection between lipid peroxidation and a distinctive cell death pathway, the search for new small molecules able to suppress lipid peroxidation has gained momentum and may yield novel cytoprotective strategies. We review here advances in our understanding of the ferroptotic process and summarize the development of lipid peroxidation inhibitors with the ultimate goal of suppressing ferroptosis-relevant cell death and related pathologies. |
doi_str_mv | 10.1016/j.tips.2017.02.005 |
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This has come with our understanding that several distinct forms of cell death are encompassed under the umbrella term necrosis. Among these distinct forms of regulated necrotic cell death, ferroptosis has attracted considerable attention owing to its putative involvement in diverse pathophysiological processes. A key feature of the ferroptosis process is the requirement of phospholipid peroxidation, a process that has been linked with several human pathologies. Now with the establishment of a connection between lipid peroxidation and a distinctive cell death pathway, the search for new small molecules able to suppress lipid peroxidation has gained momentum and may yield novel cytoprotective strategies. 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subjects | Advanced Basic Science Animals Apoptosis - physiology cell death cysteine metabolism Fatty Acids - pharmacology glutathione peroxidase Humans Iron - physiology lipid peroxidation Lipid Peroxidation - drug effects regulated necrosis small molecules |
title | Ferroptosis Inhibition: Mechanisms and Opportunities |
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