Ferroptosis Inhibition: Mechanisms and Opportunities

The past decade has yielded tremendous insights into how cells die. This has come with our understanding that several distinct forms of cell death are encompassed under the umbrella term necrosis. Among these distinct forms of regulated necrotic cell death, ferroptosis has attracted considerable att...

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Veröffentlicht in:Trends in pharmacological sciences (Regular ed.) 2017-05, Vol.38 (5), p.489-498
Hauptverfasser: Angeli, Jose Pedro Friedmann, Shah, Ron, Pratt, Derek A, Conrad, Marcus
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container_title Trends in pharmacological sciences (Regular ed.)
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creator Angeli, Jose Pedro Friedmann
Shah, Ron
Pratt, Derek A
Conrad, Marcus
description The past decade has yielded tremendous insights into how cells die. This has come with our understanding that several distinct forms of cell death are encompassed under the umbrella term necrosis. Among these distinct forms of regulated necrotic cell death, ferroptosis has attracted considerable attention owing to its putative involvement in diverse pathophysiological processes. A key feature of the ferroptosis process is the requirement of phospholipid peroxidation, a process that has been linked with several human pathologies. Now with the establishment of a connection between lipid peroxidation and a distinctive cell death pathway, the search for new small molecules able to suppress lipid peroxidation has gained momentum and may yield novel cytoprotective strategies. We review here advances in our understanding of the ferroptotic process and summarize the development of lipid peroxidation inhibitors with the ultimate goal of suppressing ferroptosis-relevant cell death and related pathologies.
doi_str_mv 10.1016/j.tips.2017.02.005
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subjects Advanced Basic Science
Animals
Apoptosis - physiology
cell death
cysteine metabolism
Fatty Acids - pharmacology
glutathione peroxidase
Humans
Iron - physiology
lipid peroxidation
Lipid Peroxidation - drug effects
regulated necrosis
small molecules
title Ferroptosis Inhibition: Mechanisms and Opportunities
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