Brief Report: High Sensitivity and Specificity of the Cepheid Xpert HIV-1 Qualitative Point-of-Care Test Among Newborns in Botswana

Brief Report: High Sensitivity and Specificity of the Cepheid Xpert HIV-1 Qualitative Point-of-Care Test Among Newborns in Botswana

BACKGROUND:HIV point-of-care (POC) testing allows for early infant HIV diagnosis and treatment, but POC accuracy at birth and in the setting of antiretroviral prophylaxis for the prevention of mother-to-child HIV transmission is unknown. METHODS:We evaluated the Cepheid Xpert HIV-1 Qual POC test aga...

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Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) 2017-08, Vol.75 (5), p.e128-e131
Hauptverfasser: Ibrahim, Maryanne, Moyo, Sikhulile, Mohammed, Terence, Mupfumi, Lucy, Gaseitsiwe, Simani, Maswabi, Kenneth, Ajibola, Gbolahan, Gelman, Rebecca, Batlang, Oganne, Sakoi, Maureen, Auletta-Young, Chloe, Makhema, Joseph, Lockman, Shahin, Shapiro, Roger L
Format: Artikel
Sprache:eng
Schlagworte:
Adult
AIDS/HIV
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral therapy
Botswana
Confidence intervals
Deoxyribonucleic acid
Diagnosis
Disease transmission
DNA
DNA polymerase
DNA-directed DNA polymerase
Drug delivery systems
Early Diagnosis
Enzyme Assays - methods
Female
HIV
HIV Infections - diagnosis
HIV Infections - prevention & control
HIV Infections - transmission
Human immunodeficiency virus
Humans
Infant, Newborn
Infants
Infections
Infectious Disease Transmission, Vertical - prevention & control
Male
Medical tests
Neonates
Nevirapine
Newborn babies
Point-of-Care Systems
Polymerase chain reaction
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Prophylaxis
Qualitative research
Ribonucleic acid
RNA
RNA, Viral
Sensitivity
Sensitivity analysis
Sensitivity and Specificity
Spots
Viral Load
Zidovudine
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Zusammenfassung:BACKGROUND:HIV point-of-care (POC) testing allows for early infant HIV diagnosis and treatment, but POC accuracy at birth and in the setting of antiretroviral prophylaxis for the prevention of mother-to-child HIV transmission is unknown. METHODS:We evaluated the Cepheid Xpert HIV-1 Qual POC test against the Roche Taqman HIV-1 DNA polymerase chain reaction (PCR) platform using dried blood spots from 15 HIV-infected and 75 HIV-exposed uninfected newborns. These infants were screened for HIV at
ISSN:1525-4135
1944-7884
DOI:10.1097/QAI.0000000000001384