Defining an inflamed tumor immunophenotype in recurrent, metastatic squamous cell carcinoma of the head and neck
Highlights • We identified a group of R/M SCCHN tumors with an inflamed immunophenotype. • We identified a non-inflamed tumor immunophenotype in the same population. • Patients with the inflamed tumor phenotype had improved survival. • Patients with the inflamed tumor phenotype may benefit from chec...
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| Veröffentlicht in: | Oral oncology 2017-04, Vol.67, p.61-69 |
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| container_title | Oral oncology |
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| creator | Hanna, Glenn J Liu, Hongye Jones, Robert E Bacay, Alyssa F Lizotte, Patrick H Ivanova, Elena V Bittinger, Mark A Cavanaugh, Megan E Rode, Amanda J Schoenfeld, Jonathan D Chau, Nicole G Haddad, Robert I Lorch, Jochen H Wong, Kwok-Kin Uppaluri, Ravindra Hammerman, Peter S |
| description | Highlights • We identified a group of R/M SCCHN tumors with an inflamed immunophenotype. • We identified a non-inflamed tumor immunophenotype in the same population. • Patients with the inflamed tumor phenotype had improved survival. • Patients with the inflamed tumor phenotype may benefit from checkpoint blockade. |
| doi_str_mv | 10.1016/j.oraloncology.2017.02.005 |
| format | Article |
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| subjects | Adult Aged Aged, 80 and over Biomarkers Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - pathology Female Head and neck cancer Head and Neck Neoplasms - immunology Head and Neck Neoplasms - pathology Hematology, Oncology and Palliative Medicine Humans Immunophenotyping Immunotherapy Male Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local Otolaryngology PD-1 Squamous Cell Carcinoma of Head and Neck Survival |
| title | Defining an inflamed tumor immunophenotype in recurrent, metastatic squamous cell carcinoma of the head and neck |
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