Defining an inflamed tumor immunophenotype in recurrent, metastatic squamous cell carcinoma of the head and neck

Highlights • We identified a group of R/M SCCHN tumors with an inflamed immunophenotype. • We identified a non-inflamed tumor immunophenotype in the same population. • Patients with the inflamed tumor phenotype had improved survival. • Patients with the inflamed tumor phenotype may benefit from chec...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oral oncology 2017-04, Vol.67, p.61-69
Hauptverfasser:	Hanna, Glenn J, Liu, Hongye, Jones, Robert E, Bacay, Alyssa F, Lizotte, Patrick H, Ivanova, Elena V, Bittinger, Mark A, Cavanaugh, Megan E, Rode, Amanda J, Schoenfeld, Jonathan D, Chau, Nicole G, Haddad, Robert I, Lorch, Jochen H, Wong, Kwok-Kin, Uppaluri, Ravindra, Hammerman, Peter S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - pathology Female Head and neck cancer Head and Neck Neoplasms - immunology Head and Neck Neoplasms - pathology Hematology, Oncology and Palliative Medicine Humans Immunophenotyping Immunotherapy Male Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local Otolaryngology PD-1 Squamous Cell Carcinoma of Head and Neck Survival
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • We identified a group of R/M SCCHN tumors with an inflamed immunophenotype. • We identified a non-inflamed tumor immunophenotype in the same population. • Patients with the inflamed tumor phenotype had improved survival. • Patients with the inflamed tumor phenotype may benefit from checkpoint blockade.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2017.02.005