Enhanced activity of macrophage M1/M2 phenotypes in periodontitis

Highlights • In this study, we are the first one to find that the ratio of M1/M2 was significant higher in periodontitis group compared with that in gingivitis one. • In addition, the relative expressions of IL-1β and MMP-9 also increased in periodontitis group and was correlated with the ratios of...

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Veröffentlicht in:	Archives of oral biology 2018-12, Vol.96, p.234-242
Hauptverfasser:	Yang, Jingmei, Zhu, Yan, Duan, Dingyu, Wang, Panpan, Xin, Yuejiao, Bai, Lin, Liu, Yiying, Xu, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Advanced Basic Science Dentistry Female Gingivitis - metabolism Humans Immunohistochemistry Interleukin-1beta - metabolism Macrophages - metabolism Male Matrix Metalloproteinase 9 - metabolism Periodontal Index Periodontitis - metabolism Phenotype Real-Time Polymerase Chain Reaction
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Zusammenfassung:	Highlights • In this study, we are the first one to find that the ratio of M1/M2 was significant higher in periodontitis group compared with that in gingivitis one. • In addition, the relative expressions of IL-1β and MMP-9 also increased in periodontitis group and was correlated with the ratios of M1/M2. • PD was positively correlated with ratios of M1/M2. • Therefore, analysis of M1/M2 ratio may provide us useful information on the periodontal health status.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2017.03.006