Stereotactic Ablative Radiotherapy Induces Peripheral T-Cell Activation in Patients with Early-Stage Lung Cancer

Figure 2A shows that in PD-11 CD4 and CD8 T cells, the fractions of IFN-g-producing cells were larger than in the PD-12 T cell populations (P < 0.001 for both CD4 and CD8 T cells), indicating that the PD-11 cells are more functionally active than the PD-12 T cells. [...]in four of nine SABR-treated patients (one patient had a nonevaluable sample at baseline), PD-11 proportions increased at least more than 4%. [...]combinations of surgery and radiotherapy treatment are sometimes administered in the context of postsurgical adjuvant radiotherapy (10). [...]a phase 2 clinical trial is currently recruiting to evaluate this hypothesis (11). [...]SABR induces systemic T-cell activation, characterized by PD1 expression in a subset of patients, whereas surgery does not.