Microbiota differences between commercial breeders impacts the post-stroke immune response

Microbiota differences between commercial breeders impacts the post-stroke immune response

Highlights • The gut microbiota composition differs between mice from different breeders. • Differences in microbiota composition correlates to changes in T cell polarization. • Microbiota-dependent T cell polarization affects immunotherapeutic efficacy.

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Bibliographische Detailangaben
Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2017-11, Vol.66, p.23-30
Hauptverfasser: Sadler, Rebecca, Singh, Vikramjeet, Benakis, Corinne, Garzetti, Debora, Brea, David, Stecher, Bärbel, Anrather, Josef, Liesz, Arthur
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
CD28 Antigens - administration & dosage
CD28 Antigens - immunology
Encephalitis - immunology
Encephalitis - metabolism
Female
Gastrointestinal Microbiome
Immunology
Immunotherapy
Lymphocyte Activation
Male
Mice, Inbred C57BL
Microbiota
Neuroinflammation
Psychiatry
Reproducibility of Results
Stroke
Stroke - immunology
Stroke - therapy
T cells
T-Lymphocytes - physiology
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Beschreibung
Zusammenfassung:Highlights • The gut microbiota composition differs between mice from different breeders. • Differences in microbiota composition correlates to changes in T cell polarization. • Microbiota-dependent T cell polarization affects immunotherapeutic efficacy.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2017.03.011