Effects of high‐protein diets on fat‐free mass and muscle protein synthesis following weight loss: a randomized controlled trial

The purpose of this work was to determine the effects of varying levels of dietary protein on body composition and muscle protein synthesis during energy deficit (ED). A randomized controlled trial of 39 adults assigned the subjects diets providing protein at 0.8 (recommended dietary allowance; RDA)...

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Veröffentlicht in:	The FASEB journal 2013-09, Vol.27 (9), p.3837-3847
Hauptverfasser:	Pasiakos, Stefan M., Cao, Jay J., Margolis, Lee M., Sauter, Edward R., Whigham, Leah D., McClung, James P., Rood, Jennifer C., Carbone, John W., Combs, Gerald F., Young, Andrew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adults Anthropometry Body Composition - drug effects Body Composition - physiology body fat body mass index dietary protein Dietary Proteins - pharmacology dual-energy X-ray absorptiometry energy deficit energy intake Energy Intake - drug effects Female fractional synthesis rate high protein diet Humans lean body mass Male muscle protein Muscle Proteins - metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism nitrogen balance postprandial Postprandial Period protein intake protein synthesis randomized clinical trials recommended dietary allowance Recommended Dietary Allowances skeletal muscle volunteers weight control weight loss Weight Loss - drug effects Weight Loss - physiology Young Adult
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Zusammenfassung:	The purpose of this work was to determine the effects of varying levels of dietary protein on body composition and muscle protein synthesis during energy deficit (ED). A randomized controlled trial of 39 adults assigned the subjects diets providing protein at 0.8 (recommended dietary allowance; RDA), 1.6 (2X‐RDA), and 2.4 (3X‐RDA) g kg–1 d–1 for 31 d. A 10‐d weight‐maintenance (WM) period was followed by a 21 d, 40% ED. Body composition and postabsorptive and postprandial muscle protein synthesis were assessed during WM (d 9‐10) and ED (d 30‐31). Volunteers lost (P
ISSN:	0892-6638 1530-6860
DOI:	10.1096/fj.13-230227