Serum 25-hydroxyvitamin D cutoffs for functional bone measures in postmenopausal osteoporosis

Summary This study sought to determine the minimal serum 25-hydroxyvitamin D [25(OH)D] concentration required to maintain bone health in postmenopausal women with low bone mass. A serum 25(OH)D concentration of 20 ng/mL rather than 30 ng/mL was appropriate for bone health. Introduction There is no c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Osteoporosis international 2017-04, Vol.28 (4), p.1377-1384
Hauptverfasser:	Lee, D. Y., Jee, J. H., Cho, Y. Y., Jang, J. Y., Yu, T. Y., Kim, T. H., Hong, Y. J., Hong, W.-J., Jin, S.-M., Hur, K. Y., Kim, J. H., Kim, S. W., Chung, J. H., Lee, M. K., Min, Y.-K.
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Aged Alkaline phosphatase Biochemical markers Biomarkers - blood Bone Density - physiology Bone mass Bone mineral density Bone Remodeling - physiology Bone turnover Chromatography, Liquid - methods Collagen Cross-linking Densitometry Endocrinology Female Femur Femur - physiopathology Femur Neck - physiopathology Humans Liquid chromatography Mass spectroscopy Medical records Medicine Medicine & Public Health Middle Aged Neck Original Article Orthopedics Osteopenia Osteoporosis Osteoporosis, Postmenopausal - blood Osteoporosis, Postmenopausal - etiology Osteoporosis, Postmenopausal - physiopathology Parathyroid hormone Parathyroid Hormone - blood Post-menopause Rheumatology Studies Tandem Mass Spectrometry - methods Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - physiopathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary This study sought to determine the minimal serum 25-hydroxyvitamin D [25(OH)D] concentration required to maintain bone health in postmenopausal women with low bone mass. A serum 25(OH)D concentration of 20 ng/mL rather than 30 ng/mL was appropriate for bone health. Introduction There is no consensus on the minimal serum 25-hydroxyvitamin D [25(OH)D] concentration required to maintain bone health. The aim of this study was to investigate the relationship between 25(OH)D measured via liquid chromatography-mass spectrometry (LC–MS/MS), which is the current gold standard, and biochemical markers of bone turnover, PTH, and bone mineral densitometry (BMD). Methods The medical records of 750 postmenopausal women newly diagnosed with osteoporosis or osteopenia at Samsung Medical Center from 2009 to 2014 were investigated. Subjects were divided into four groups according to serum 25(OH)D concentration:
ISSN:	0937-941X 1433-2965
DOI:	10.1007/s00198-016-3892-0