Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells

Gomisin N, which is a lignan isolated from Schisandra chinensis , has some pharmacological effects. However, the anti-inflammatory effects of gomisin N on periodontal disease are uncertain. The aim of this study was to examine the effect of gomisin N on inflammatory mediator production in tumor necr...

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Veröffentlicht in:Inflammation 2017-04, Vol.40 (2), p.360-365
Hauptverfasser: Hosokawa, Yoshitaka, Hosokawa, Ikuko, Shindo, Satoru, Ozaki, Kazumi, Matsuo, Takashi
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Sprache:eng
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Zusammenfassung:Gomisin N, which is a lignan isolated from Schisandra chinensis , has some pharmacological effects. However, the anti-inflammatory effects of gomisin N on periodontal disease are uncertain. The aim of this study was to examine the effect of gomisin N on inflammatory mediator production in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLC). Gomisin N inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 2, and CCL20 production in TNF-α-stimulated HPDLC in a dose-dependent manner. Moreover, we revealed that gomisin N could suppress extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) phosphorylation in TNF-α-stimulated HPDLC though protein kinase B (Akt) phosphorylation was not suppressed by gomisin N treatment. In summary, gomisin N might exert anti-inflammatory effects by attenuating cytokine production in periodontal ligament cells via inhibiting the TNF-α-stimulated ERK and JNK pathways activation.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-016-0482-4