Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications
Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated pr...
Gespeichert in:
| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2017, Vol.53 (8), p.1366-1369 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1369 |
|---|---|
| container_issue | 8 |
| container_start_page | 1366 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 53 |
| creator | Zhang, Qingyang Wang, Qinghua Xu, Shengnan Zuo, Limin You, Xuefu Hu, Hai-Yu |
| description | Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus. |
| doi_str_mv | 10.1039/c6cc08292k |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1881751659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1881751659</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-dfa063a5fb7d433aa80a7a47995bd51a7477c8e7e5028be6ac5e7390f47df6ec3</originalsourceid><addsrcrecordid>eNqNkU1LxDAQhoMo7vpx8QdIjyJUkyZpkuNS_ELBi6K3Mk2mGu02tekK---tu6vnncvMwMM7Aw8hJ4xeMMrNpc2tpToz2ecOmTKei1QK_br7O0uTKi7khBzE-EHHYlLvk0mmDJc5k1PyMpv7Nrw1Sxuid5hWENElbfjGJun6UGFM6tAnFdgBew9N4jy8tSEO3ibQumR4xx46XKz2rmu8hcGHNh6RvRqaiMebfkier6-eitv04fHmrpg9pJZLPqSuBppzkHWlnOAcQFNQIJQxsnKSgRJKWY0KJc10hTlYiYobWgvl6hwtPyRn69zx2a8FxqGc-2ixaaDFsIgl05opyXJptkDHs8ZoyrZAhdImk1KM6PkatX2Isce67Ho_h35ZMlr-6imLvChWeu5H-HSTu6jm6P7RPx_8BwAyi4E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1847892554</pqid></control><display><type>article</type><title>Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Zhang, Qingyang ; Wang, Qinghua ; Xu, Shengnan ; Zuo, Limin ; You, Xuefu ; Hu, Hai-Yu</creator><creatorcontrib>Zhang, Qingyang ; Wang, Qinghua ; Xu, Shengnan ; Zuo, Limin ; You, Xuefu ; Hu, Hai-Yu</creatorcontrib><description>Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c6cc08292k</identifier><identifier>PMID: 27935615</identifier><language>eng</language><publisher>England</publisher><subject>Aminoglycosides - analysis ; Aminoglycosides - chemistry ; Aminoglycosides - pharmacology ; Aminoglycosides - therapeutic use ; Analogs ; Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Bacteria ; Damage ; Infectious diseases ; Killing ; Labelling ; Methicillin-Resistant Staphylococcus aureus - cytology ; Methicillin-Resistant Staphylococcus aureus - drug effects ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Mice ; Microbial Sensitivity Tests ; Molecular Probes - analysis ; Molecular Probes - chemistry ; Molecular Probes - pharmacology ; Molecular Probes - therapeutic use ; Molecular Structure ; Neomycin - analogs & derivatives ; Neomycin - chemistry ; Neomycin - pharmacology ; Neomycin - therapeutic use ; Particle Size ; Pathogens ; RAW 264.7 Cells ; Staphylococcal Infections - diagnosis ; Staphylococcal Infections - microbiology ; Staphylococcal Infections - therapy ; Staphylococcus aureus ; Strategy</subject><ispartof>Chemical communications (Cambridge, England), 2017, Vol.53 (8), p.1366-1369</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-dfa063a5fb7d433aa80a7a47995bd51a7477c8e7e5028be6ac5e7390f47df6ec3</citedby><cites>FETCH-LOGICAL-c353t-dfa063a5fb7d433aa80a7a47995bd51a7477c8e7e5028be6ac5e7390f47df6ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27935615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Qingyang</creatorcontrib><creatorcontrib>Wang, Qinghua</creatorcontrib><creatorcontrib>Xu, Shengnan</creatorcontrib><creatorcontrib>Zuo, Limin</creatorcontrib><creatorcontrib>You, Xuefu</creatorcontrib><creatorcontrib>Hu, Hai-Yu</creatorcontrib><title>Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus.</description><subject>Aminoglycosides - analysis</subject><subject>Aminoglycosides - chemistry</subject><subject>Aminoglycosides - pharmacology</subject><subject>Aminoglycosides - therapeutic use</subject><subject>Analogs</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacteria</subject><subject>Damage</subject><subject>Infectious diseases</subject><subject>Killing</subject><subject>Labelling</subject><subject>Methicillin-Resistant Staphylococcus aureus - cytology</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Methicillin-Resistant Staphylococcus aureus - isolation & purification</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Probes - analysis</subject><subject>Molecular Probes - chemistry</subject><subject>Molecular Probes - pharmacology</subject><subject>Molecular Probes - therapeutic use</subject><subject>Molecular Structure</subject><subject>Neomycin - analogs & derivatives</subject><subject>Neomycin - chemistry</subject><subject>Neomycin - pharmacology</subject><subject>Neomycin - therapeutic use</subject><subject>Particle Size</subject><subject>Pathogens</subject><subject>RAW 264.7 Cells</subject><subject>Staphylococcal Infections - diagnosis</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal Infections - therapy</subject><subject>Staphylococcus aureus</subject><subject>Strategy</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1LxDAQhoMo7vpx8QdIjyJUkyZpkuNS_ELBi6K3Mk2mGu02tekK---tu6vnncvMwMM7Aw8hJ4xeMMrNpc2tpToz2ecOmTKei1QK_br7O0uTKi7khBzE-EHHYlLvk0mmDJc5k1PyMpv7Nrw1Sxuid5hWENElbfjGJun6UGFM6tAnFdgBew9N4jy8tSEO3ibQumR4xx46XKz2rmu8hcGHNh6RvRqaiMebfkier6-eitv04fHmrpg9pJZLPqSuBppzkHWlnOAcQFNQIJQxsnKSgRJKWY0KJc10hTlYiYobWgvl6hwtPyRn69zx2a8FxqGc-2ixaaDFsIgl05opyXJptkDHs8ZoyrZAhdImk1KM6PkatX2Isce67Ho_h35ZMlr-6imLvChWeu5H-HSTu6jm6P7RPx_8BwAyi4E</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Zhang, Qingyang</creator><creator>Wang, Qinghua</creator><creator>Xu, Shengnan</creator><creator>Zuo, Limin</creator><creator>You, Xuefu</creator><creator>Hu, Hai-Yu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>2017</creationdate><title>Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications</title><author>Zhang, Qingyang ; Wang, Qinghua ; Xu, Shengnan ; Zuo, Limin ; You, Xuefu ; Hu, Hai-Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-dfa063a5fb7d433aa80a7a47995bd51a7477c8e7e5028be6ac5e7390f47df6ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aminoglycosides - analysis</topic><topic>Aminoglycosides - chemistry</topic><topic>Aminoglycosides - pharmacology</topic><topic>Aminoglycosides - therapeutic use</topic><topic>Analogs</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacteria</topic><topic>Damage</topic><topic>Infectious diseases</topic><topic>Killing</topic><topic>Labelling</topic><topic>Methicillin-Resistant Staphylococcus aureus - cytology</topic><topic>Methicillin-Resistant Staphylococcus aureus - drug effects</topic><topic>Methicillin-Resistant Staphylococcus aureus - isolation & purification</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Probes - analysis</topic><topic>Molecular Probes - chemistry</topic><topic>Molecular Probes - pharmacology</topic><topic>Molecular Probes - therapeutic use</topic><topic>Molecular Structure</topic><topic>Neomycin - analogs & derivatives</topic><topic>Neomycin - chemistry</topic><topic>Neomycin - pharmacology</topic><topic>Neomycin - therapeutic use</topic><topic>Particle Size</topic><topic>Pathogens</topic><topic>RAW 264.7 Cells</topic><topic>Staphylococcal Infections - diagnosis</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal Infections - therapy</topic><topic>Staphylococcus aureus</topic><topic>Strategy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qingyang</creatorcontrib><creatorcontrib>Wang, Qinghua</creatorcontrib><creatorcontrib>Xu, Shengnan</creatorcontrib><creatorcontrib>Zuo, Limin</creatorcontrib><creatorcontrib>You, Xuefu</creatorcontrib><creatorcontrib>Hu, Hai-Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qingyang</au><au>Wang, Qinghua</au><au>Xu, Shengnan</au><au>Zuo, Limin</au><au>You, Xuefu</au><au>Hu, Hai-Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2017</date><risdate>2017</risdate><volume>53</volume><issue>8</issue><spage>1366</spage><epage>1369</epage><pages>1366-1369</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus.</abstract><cop>England</cop><pmid>27935615</pmid><doi>10.1039/c6cc08292k</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2017, Vol.53 (8), p.1366-1369 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1881751659 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Aminoglycosides - analysis Aminoglycosides - chemistry Aminoglycosides - pharmacology Aminoglycosides - therapeutic use Analogs Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteria Damage Infectious diseases Killing Labelling Methicillin-Resistant Staphylococcus aureus - cytology Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - isolation & purification Mice Microbial Sensitivity Tests Molecular Probes - analysis Molecular Probes - chemistry Molecular Probes - pharmacology Molecular Probes - therapeutic use Molecular Structure Neomycin - analogs & derivatives Neomycin - chemistry Neomycin - pharmacology Neomycin - therapeutic use Particle Size Pathogens RAW 264.7 Cells Staphylococcal Infections - diagnosis Staphylococcal Infections - microbiology Staphylococcal Infections - therapy Staphylococcus aureus Strategy |
| title | Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T07%3A36%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aminoglycoside-based%20novel%20probes%20for%20bacterial%20diagnostic%20and%20therapeutic%20applications&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Zhang,%20Qingyang&rft.date=2017&rft.volume=53&rft.issue=8&rft.spage=1366&rft.epage=1369&rft.pages=1366-1369&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c6cc08292k&rft_dat=%3Cproquest_cross%3E1881751659%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1847892554&rft_id=info:pmid/27935615&rfr_iscdi=true |