Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications

Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated pr...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2017, Vol.53 (8), p.1366-1369
Hauptverfasser:	Zhang, Qingyang, Wang, Qinghua, Xu, Shengnan, Zuo, Limin, You, Xuefu, Hu, Hai-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides - analysis Aminoglycosides - chemistry Aminoglycosides - pharmacology Aminoglycosides - therapeutic use Analogs Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteria Damage Infectious diseases Killing Labelling Methicillin-Resistant Staphylococcus aureus - cytology Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - isolation & purification Mice Microbial Sensitivity Tests Molecular Probes - analysis Molecular Probes - chemistry Molecular Probes - pharmacology Molecular Probes - therapeutic use Molecular Structure Neomycin - analogs & derivatives Neomycin - chemistry Neomycin - pharmacology Neomycin - therapeutic use Particle Size Pathogens RAW 264.7 Cells Staphylococcal Infections - diagnosis Staphylococcal Infections - microbiology Staphylococcal Infections - therapy Staphylococcus aureus Strategy
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Beschreibung
Zusammenfassung:	Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c6cc08292k