Sequence-encoded material properties dictate the structure and function of nuclear bodies

Highlights • Nuclear bodies (NBs) are phase-separated membraneless organelles. • Amino acid sequences of NB components confer liquid-like or solid-like behavior. • Differences in material properties of immiscible phases drive core/shell structure. • Concentration of enzymes within NBs can enhance or...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in cell biology 2017-06, Vol.46, p.62-71
1. Verfasser:	Weber, Stephanie C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleolus - chemistry Cell Nucleolus - metabolism Cell Nucleus - chemistry Cell Nucleus - metabolism Humans Internal Medicine Intranuclear Inclusion Bodies - chemistry Intranuclear Inclusion Bodies - metabolism Ribosomes - metabolism RNA Processing, Post-Transcriptional Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Nuclear bodies (NBs) are phase-separated membraneless organelles. • Amino acid sequences of NB components confer liquid-like or solid-like behavior. • Differences in material properties of immiscible phases drive core/shell structure. • Concentration of enzymes within NBs can enhance or inhibit their function.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/j.ceb.2017.03.003