Perioperative hemoglobin A1c as a predictor of deep infection following single level lumbar decompression in patients with diabetes

Abstract Background Context Although multiple studies have cited diabetes mellitus as a risk factor decreased functional outcomes, increased infectious complications, and overall increased reoperation rate following degenerative lumbar spinal surgery, few have investigated how perioperative glycemic control influences such complications. Purpose The primary goal of the present study was to use a national database to evaluate the association of perioperative glycemic control as demonstrated by Hemoglobin A1c levels in patients with diabetes undergoing primary, single level decompression without concomitant fusion with the incidence of deep postoperative infection following requiring operative irrigation and debridement. Our secondary objective was to calculate a threshold level of HbA1c above which the risk of postoperative infection after lumbar decompression increases significantly in patients with diabetes. Study Design/Setting Retrospective case control database study, Level III Evidence Patient Sample This study comprised private-payer patients with diabetes mellitus undergoing single level lumbar decompression with a hemoglobin A1c lab value recorded in the database within 3 months of surgery. Outcome Measures The outcome examined in this study was deep infection following primary single level lumbar decompression requiring surgical intervention. Postoperative infection within one year of the index primary single level lumbar decompression was assessed using Current Procedural Terminology procedure codes and International Classification of Diseases, 9th Revision diagnostic codes. Methods The Humana private-payer dataset from the PearlDiver database was used for this study. The database was queried for patients with diabetes mellitus undergoing primary, single-level lumbar decompression surgery using Current Procedural Terminology codes. Patients with a diagnosis of diabetes mellitus who had an HbA1c level drawn within 3 months before or after their surgical date were then selected to form the study group using International Classification of Diseases, 9th Revision diagnostic codes. Patients were then grouped into groups based on their HbA1c level by increments of 0.5 mg/dL. The incidence of deep infection requiring operative intervention within 1 year for each HbA1c group was then identified using CPT and ICD-9 codes. A receiver operating characteristic (ROC) and area under the curve analysis was performed to determine an optimal threshold value of th