Set up of cutoff thresholds for kinship determination using SNP loci

Set up of cutoff thresholds for kinship determination using SNP loci

Highlights • Discriminatory power of 80 SNP loci was suitable for parent-child relationships. • Applying 136 SNP loci applied to analysis was sufficient for full-sibling determination with the highest accuracy and sensitivity. • Indistinguishable full-sibling relationships with only 15 STR data were...

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Veröffentlicht in:Forensic science international : genetics 2017-07, Vol.29, p.1-8
Hauptverfasser: Cho, Sohee, Shin, Eun Soon, Yu, Hyung Jin, Lee, Ji Hyun, Seo, Hee Jin, Kim, Moon Young, Lee, Soong Deok
Format: Artikel
Sprache:eng
Schlagworte:
Asian Continental Ancestry Group - genetics
Forensic Genetics
Full-sibling
Humans
Kinship
Likelihood Functions
Likelihood ratio
Linkage Disequilibrium
Pathology
Pedigree
Polymorphism, Single Nucleotide
Republic of Korea
Single nucleotide polymorphism
Uncle-nephew
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Beschreibung
Zusammenfassung:Highlights • Discriminatory power of 80 SNP loci was suitable for parent-child relationships. • Applying 136 SNP loci applied to analysis was sufficient for full-sibling determination with the highest accuracy and sensitivity. • Indistinguishable full-sibling relationships with only 15 STR data were successfully resolved by SNP data with significant difference in the median value.
ISSN:1872-4973
1878-0326
DOI:10.1016/j.fsigen.2017.03.009