Bioactive constituents from transformed root cultures of Nepeta teydea

A phytochemical study of an extract from transformed root cultures of Nepeta teydea, induced by Agrobacterium rhizogenes, led to the isolation of the following new compounds: the sesquiterpene (-)-cinalbicol, the diterpene teydeadione (6,11,14-trihydroxy-12-methoxy-abieta-5,8,11,13,15-penten-7-one), a degraded C23-triterpene (teydealdehyde) and three fatty acid esters of lanosta-7,24-dien-3β-ol. The propyl ester of rosmarinic acid was also isolated for the first time from a natural source. In addition, two dehydroabietane diterpenes, eight triterpenes and eighteen known phenolic compounds were obtained. The antifeedant, cytotoxic and phytotoxic activities of the isolated compounds have also been investigated. A study of Nepeta teydea root cultures afforded the undescribed compounds (-)-cinalbicol, teydeadione, teydealdehyde, and three fatty esters of lanosta-7,24-dien-3β-ol. The antifeedant, cytotoxic and phytotoxic activities of the constituents of the root cultures have also been investigated. [Display omitted] •Components of transformed root cultures of Nepeta teydea have been studied.•New compounds: (-)-cinalbicol, teydeadione, teydealdehyde, lanostadiene esters.•The antifeedant, cytotoxic and phytotoxic activities have been investigated.