Impact of β-lactam antibiotic therapeutic drug monitoring on dose adjustments in critically ill patients undergoing continuous renal replacement therapy

Impact of β-lactam antibiotic therapeutic drug monitoring on dose adjustments in critically ill patients undergoing continuous renal replacement therapy

Highlights •Antibiotic dosing in continuous renal replacement therapy in ICU patients is highly challenging. • Over one-third of patients had concentrations outside the therapeutic range. • 24% of therapeutic drug monitoring (TDM) results manifested unnecessarily high antibiotic concentrations. • TD...

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Veröffentlicht in:International journal of antimicrobial agents 2017-05, Vol.49 (5), p.589-594
Hauptverfasser: Economou, Caleb J.P, Wong, Gloria, McWhinney, Brett, Ungerer, Jacobus P.J, Lipman, Jeffrey, Roberts, Jason A
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Bacteremia - drug therapy
beta-Lactams - administration & dosage
beta-Lactams - therapeutic use
Continuous renal replacement therapy
Critical Care
Critical Illness
Cross Infection - drug therapy
Drug Monitoring - methods
Female
Humans
Infectious Disease
Intensive Care Units
Male
Microbial Sensitivity Tests
Middle Aged
Pharmacodynamics
Pharmacokinetics
Pneumonia, Bacterial - drug therapy
Renal Replacement Therapy - methods
Retrospective Studies
TDM
Tertiary Care Centers
Therapeutic drug monitoring
Young Adult
β-Lactam antibiotic
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Beschreibung
Zusammenfassung:Highlights •Antibiotic dosing in continuous renal replacement therapy in ICU patients is highly challenging. • Over one-third of patients had concentrations outside the therapeutic range. • 24% of therapeutic drug monitoring (TDM) results manifested unnecessarily high antibiotic concentrations. • TDM is useful for ensuring optimised dosing. • Hospital-acquired pneumonia patients had the highest rates of excessive antibiotic concentrations.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2017.01.009